Scientists Identify Kratom's LD50 By Injecting & Orally Overdosing Mice, Claim It's As Deadly As Heroin & Develop Urine Drug Test

"For thousands of people, the opioid-like plant kratom has been life-changing. But like many drugs, it’s not without potential risks. While patient interviews have revealed that kratom can offer some patients with chronic health conditions the relief that conventional opioids hadn’t and in some cases curbed dangerous opioid use, reality isn’t always so neat and clean. New research indicates that high enough doses of the two active molecules in kratom can cause death in mice, suggesting that it is possible to fatally overdose on the substance.

In a paper published October 31 in the journal Chemical Research in Toxicology, a team of researchers tested mitragynine and 7-hydroxymitragynine, the two main active molecules in kratom, on mice to establish their LD50 — a measure of lethal dosage. When researchers injected these chemicals into mice intravenously, they were lethal at around the same dosage as heroin.

Whereas the mice injected with heroin died from an average dose of 23.7 milligrams per kilogram of body weight (mg/kgbw), the mice injected with mitragynine died from 27.8 mg/kgbw, and those injected with 7-hydroxymitragynine died from 24.7 mg/kgbw. The researchers found 547.7 mg/kgbw to be the average lethal dose of mitragynine when it was taken orally. None of the mice died from oral doses of 7-hydroxymitragynine, but the mice given large oral doses of 7-hydroxymitragynine experienced seizures and depressed breathing.

These doses, fortunately, are out of the typical range of a kratom dosage. For instance, a 2015 study in Drug Design, Development and Therapy gave human subjects oral doses of kratom tea containing between 6.25 and 23 mg of mitragynine. For a person weighing 220 pounds, this translates to between 0.0625 and 0.23 milligrams per kilogram of body weight, over 100 times below the LD50 for mice. Of course, some kratom users push their limits, so it’s entirely possible some users get much higher doses. Nonetheless, there’s minimal evidence that they’re taking it intravenously.

The team also developed a urine test for mitragynine and 7-hydroxymitragynine that works in a similar way to other urine drug tests: by using an antibody to detect traces of drugs. In fact, this was their primary goal with the research, says Kim Janda, Ph.D., a professor of chemistry at Scripps and the corresponding author on the study."

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I mean seriously? Injecting Kratom? LMFAO! A Human would literally have to take a shitload of Kratom's active ingredients to reach this supposed LD50 orally. Yet the FDA/DEA will use that & especially the IV part to finally Schedule Kratom or it's active ingredients. If they aren't complete assholes not all of them will be Schedule 1...



Last Edited by COSMIC WARRIOR on 11/23/2018 10:00 AM