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Terminal cancer patients in complete remission after one gene therapy treatment

 
Face Palmer
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03/01/2017 03:51 AM
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Terminal cancer patients in complete remission after one gene therapy treatment
A groundbreaking gene therapy treatment which boosts a patient's own immune cells has been shown to clear disease from one third of terminal patients.

US pharmaceutical company Kite Pharma released results from the first six months of its trial of the new treatment, called CAR-T cell therapy.

Some 36 per cent of the 101 patients on the trial were still in complete remission at six months, and eight in 10 saw their cancer shrink by at least half during the study.

"The numbers are fantastic," said Dr Fred Locke, a blood cancer expert at Moffitt Cancer Center in Tampa who co-led the study.

"These are heavily treated patients who have no other options."

The treatment, which has been dubbed 'a living drug' by doctors, works by filtering a patient's blood to remove key immune system cells called T-cells, which are then genetically engineered in the lab to recognise cancer cells.

Cancer cells are very good a evading the immune system, but the new therapy essentially cuts the brakes, allowing immune cells to do their job properly.

[link to www.telegraph.co.uk]

science
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Sungaze_At_Dawn

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03/01/2017 03:57 AM

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Re: Terminal cancer patients in complete remission after one gene therapy treatment
1/3 is not a cure.
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LightIsTheAnswer
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03/01/2017 05:09 AM
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Re: Terminal cancer patients in complete remission after one gene therapy treatment
Light therapy is a cure. Wait until you see more studies on it shortly. Can be used for many ailments.
Anonymous Coward
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03/01/2017 05:19 AM
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Re: Terminal cancer patients in complete remission after one gene therapy treatment
Hi Face. I checked this out earlier. Another lot using this cancelled it because of the high death rate due to the therapy!
Face Palmer  (OP)

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03/01/2017 05:54 AM
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Re: Terminal cancer patients in complete remission after one gene therapy treatment
Hi Face. I checked this out earlier. Another lot using this cancelled it because of the high death rate due to the therapy!
 Quoting: Tess.


Hm they are going to die anyway very soon, so I personally would take the chance I guess
"The world will soon wake up to the reality that everyone is broke and can collect nothing from the bankrupt, who are owed unlimited amounts by the insolvent, who are attempting to make late payments on a bank holiday in the wrong country, with an unacceptable currency, against defaulted collateral, of which nobody is sure who holds title."

Never attribute to malice that which is adequately explained by stupidity.

The woman who is not pursued sets up the doctrine that pursuit is offensive to her sex, and wants to make it a felony. No genuinely attractive woman has any such desire. - H.L. Mencken, In Defense Of Women
Jake

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03/01/2017 06:22 AM
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Re: Terminal cancer patients in complete remission after one gene therapy treatment
1/3 is not a cure.
 Quoting: Sungaze_At_Dawn


beats the 99% failure rate of chemo therapy
Evil controls the ignorant... Climate change is a hoax so is the vax you have been fear-porned into compliance!

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Anonymous Coward
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03/01/2017 06:53 AM
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Re: Terminal cancer patients in complete remission after one gene therapy treatment
Thanks we have been watching this as it has promise for Huntingtons
Chas

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03/01/2017 07:10 AM
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Re: Terminal cancer patients in complete remission after one gene therapy treatment
bump
Chas
Anonymous Coward
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03/01/2017 07:17 AM
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Re: Terminal cancer patients in complete remission after one gene therapy treatment
1/3 is not a cure.
 Quoting: Sungaze_At_Dawn


beats the 99% failure rate of chemo therapy
 Quoting: Jake


hesright
Chugiakian

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03/01/2017 07:17 AM
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Re: Terminal cancer patients in complete remission after one gene therapy treatment
The way modern western medicine treats cancer right now is BARBARIC~!
Chugiakian
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03/01/2017 07:17 AM
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Re: Terminal cancer patients in complete remission after one gene therapy treatment
1/3 is not a cure.
 Quoting: Sungaze_At_Dawn


beats the 99% failure rate of chemo therapy
 Quoting: Jake


hesright
 Quoting: Anonymous Coward 56915284


hesright
Chugiakian
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03/01/2017 07:19 AM

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Re: Terminal cancer patients in complete remission after one gene therapy treatment
bump
FHL(C)

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03/01/2017 07:22 AM

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Re: Terminal cancer patients in complete remission after one gene therapy treatment
Thank you FP, you do a great job.
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Anonymous Coward
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03/01/2017 07:27 AM
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Re: Terminal cancer patients in complete remission after one gene therapy treatment
1/3 is not a cure.
 Quoting: Sungaze_At_Dawn


beats the 99% failure rate of chemo therapy
 Quoting: Jake


hesright
 Quoting: Anonymous Coward 56915284


hesright
 Quoting: Chugiakian


hesright
Anonymous Coward
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03/01/2017 07:40 AM
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Re: Terminal cancer patients in complete remission after one gene therapy treatment
so do they inject the blood back into the body? sorry i'm kinda dumb :(
Anonymous Coward
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03/01/2017 07:46 AM
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Re: Terminal cancer patients in complete remission after one gene therapy treatment
The worry has been how long Kite's treatment would last and its side effects, which he said seem manageable in the study. Follow-up beyond six months is still needed to see if the benefit wanes, Herbst said, but added, "this certainly is something I would want to have available."

The therapy is not without risk. Three of the 101 patients in the study died of causes unrelated to worsening of their cancer, and two of those deaths were deemed due to the treatment.

[link to www.foxnews.com]
Anonymous Coward
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03/01/2017 07:48 AM
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Re: Terminal cancer patients in complete remission after one gene therapy treatment
Gene therapy has been held up as a silver bullet because the idea that you could pick any gene you want is so alluring," said Jessica Vargas, co-lead author of the study, who was a PhD student in the Wender lab during this research. "With mRNA, there are more limitations because the protein expression is transient, but that opens up other applications where you wouldn't use other types of gene therapy."

One especially appropriate application of this technology is vaccination. At present, vaccines require introducing part of a virus or an inactive virus into the body in order to elicit an immune response. CARTs could potentially cut out the middleman, directly instructing the body to produce its own antigens. Once the CART dissolves, the immunity remains without any leftover foreign material present.

The team is also working on applying their technique to another genetic messenger that would produce permanent effects, making it a complementary option to the temporary mRNA therapies. With the progress already made using mRNA and the potential of their ongoing research, they and others could be closer than ever to making individualized therapeutics using a person's own cells.


[link to www.sciencedaily.com (secure)]
Anonymous Coward
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03/01/2017 07:49 AM
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Re: Terminal cancer patients in complete remission after one gene therapy treatment
Video from Jan


Gene therapy heralds cure for blindness

[link to www.telegraph.co.uk]
Face Palmer  (OP)

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03/01/2017 07:53 AM
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Re: Terminal cancer patients in complete remission after one gene therapy treatment
Thank you FP, you do a great job.
 Quoting: FHL(C)


Thanks :)
"The world will soon wake up to the reality that everyone is broke and can collect nothing from the bankrupt, who are owed unlimited amounts by the insolvent, who are attempting to make late payments on a bank holiday in the wrong country, with an unacceptable currency, against defaulted collateral, of which nobody is sure who holds title."

Never attribute to malice that which is adequately explained by stupidity.

The woman who is not pursued sets up the doctrine that pursuit is offensive to her sex, and wants to make it a felony. No genuinely attractive woman has any such desire. - H.L. Mencken, In Defense Of Women
Chad
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03/01/2017 08:01 AM
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Re: Terminal cancer patients in complete remission after one gene therapy treatment
1/3 is not a cure.
 Quoting: Sungaze_At_Dawn


No, but "These are heavily treated patients who have no other options." This group had unsuccessfully tried everything else, I would expect the success rates to be much higher in the average cancer patient.
Free me

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03/01/2017 08:04 AM

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Re: Terminal cancer patients in complete remission after one gene therapy treatment
Combine it with getting all the parasites out of the system and you might have something.
Fyllefanten

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03/01/2017 08:20 AM

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Re: Terminal cancer patients in complete remission after one gene therapy treatment
SmileyWink

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Face Palmer  (OP)

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03/01/2017 08:34 AM
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Re: Terminal cancer patients in complete remission after one gene therapy treatment
The way modern western medicine treats cancer right now is BARBARIC~!
 Quoting: Chugiakian


Why barbaric???
"The world will soon wake up to the reality that everyone is broke and can collect nothing from the bankrupt, who are owed unlimited amounts by the insolvent, who are attempting to make late payments on a bank holiday in the wrong country, with an unacceptable currency, against defaulted collateral, of which nobody is sure who holds title."

Never attribute to malice that which is adequately explained by stupidity.

The woman who is not pursued sets up the doctrine that pursuit is offensive to her sex, and wants to make it a felony. No genuinely attractive woman has any such desire. - H.L. Mencken, In Defense Of Women
Anonymous Coward
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03/01/2017 08:36 AM
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Re: Terminal cancer patients in complete remission after one gene therapy treatment
1/3 is not a cure.
 Quoting: Sungaze_At_Dawn

beats the 99% failure rate of chemo therapy
 Quoting: Jake

Beats the 100% failure rate of marijuana therapy.
jkm1864

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03/01/2017 08:45 AM
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Re: Terminal cancer patients in complete remission after one gene therapy treatment
1/3 is not a cure.
 Quoting: Sungaze_At_Dawn


Reread the post. The treatment helped 80% of the people whom saw their tumors shrink.
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Anonymous Coward
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03/01/2017 08:46 AM
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Re: Terminal cancer patients in complete remission after one gene therapy treatment
Hooray for white genius.
BulletProofBeefCake

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03/01/2017 08:47 AM
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Re: Terminal cancer patients in complete remission after one gene therapy treatment
5* and karma OP, I love to hear about this kind of stuff, because I have a tumor that could eventually become cancerous at any point.
Epic Beard Guy

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03/01/2017 08:52 AM
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Re: Terminal cancer patients in complete remission after one gene therapy treatment
1/3 is not a cure.
 Quoting: Sungaze_At_Dawn


If you are in the 1/3 it is. If you are not in the 1/3, 80% saw their tumors shrink. That is great news.
The news is even better when you consider that early test are not for efficacy, they are testing for toxicity. After the toxicity tests, they will start trying figure out dosage and efficacy. This news is early, but it sounds great.
Hope for the best, but prepare for the worst.
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Anonymous Coward
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03/01/2017 08:53 AM
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Re: Terminal cancer patients in complete remission after one gene therapy treatment
1/3 is prefect. that means when fuku realy starts to impact. only 1 third (of those who can afford it) will survive.
Epic Beard Guy

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Re: Terminal cancer patients in complete remission after one gene therapy treatment
Combine it with getting all the parasites out of the system and you might have something.
 Quoting: Free me


You mean like our government and the big pharma corporations?
Hope for the best, but prepare for the worst.
"America is at that awkward stage. It's too late to work within the system, but too early to shoot the bastards." -- Claire Wolfe
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03/01/2017 09:04 AM
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Re: Terminal cancer patients in complete remission after one gene therapy treatment
A groundbreaking gene therapy treatment which boosts a patient's own immune cells has been shown to clear disease from one third of terminal patients.

US pharmaceutical company Kite Pharma released results from the first six months of its trial of the new treatment, called CAR-T cell therapy.

Some 36 per cent of the 101 patients on the trial were still in complete remission at six months, and eight in 10 saw their cancer shrink by at least half during the study.

"The numbers are fantastic," said Dr Fred Locke, a blood cancer expert at Moffitt Cancer Center in Tampa who co-led the study.

"These are heavily treated patients who have no other options."

The treatment, which has been dubbed 'a living drug' by doctors, works by filtering a patient's blood to remove key immune system cells called T-cells, which are then genetically engineered in the lab to recognise cancer cells.

Cancer cells are very good a evading the immune system, but the new therapy essentially cuts the brakes, allowing immune cells to do their job properly.

[link to www.telegraph.co.uk]

:science:
 Quoting: Face Palmer

Shit, ive been doing tbat for a decade.





GLP