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For mRNA, Covid Vaccines Are Just the Beginning |
Anonymous Coward User ID: 84645381 United States 11/05/2022 11:56 AM Report Abusive Post Report Copyright Violation | For mRNA, Covid Vaccines Are Just the Beginning For mRNA, Covid Vaccines Are Just the Beginning With clinical vaccine trials for everything from HIV to Zika, messenger RNA could transform medicine—or widen health care inequalities. [link to www.wired.com (secure)] KATALIN KARIKÓ NEVER intended to make vaccines. For years before the pandemic, the Hungarian-American biochemist had been working to realize the therapeutic potential of mRNA—first trying to create a synthetic version of the messenger molecule that wouldn’t trigger the body’s inflammatory response, and then, once she and colleague Drew Weissman had achieved that goal, trying to get the medical and scientific community to pay attention. She had envisioned the technology being used to treat those recovering from heart attacks and strokes. But it was the frantic race for a Covid vaccine that earned Karikó belated global recognition. The work she and her colleagues had done on mRNA provided the foundation for Moderna and BioNTech to quickly develop Covid vaccines that have now saved millions of lives. Traditional vaccines train the immune system by introducing it to harmless versions of whole viruses—the body learns to recognize the virus’s key features, such as SARS-CoV-2’s infamous spike protein. These new mRNA vaccines found a more elegant way to achieve the same goal, using messenger RNA—a genetic molecule found throughout nature that’s used to transmit information within and between cells—to provide the body with a set of instructions on how to make the spike protein itself, essentially borrowing the body’s internal machinery and turning it into a photocopier. This difference allowed mRNA vaccines to be designed, created, and approved in record time. Over the past 18 months, mRNA technology has been injected into billions of arms and has helped slow the devastating impact of the pandemic. But its long-term impact—accelerated by Covid—could be even greater. “It seems like the sky is the limit,” says Karikó. “Previously the belief was not there.” Dozens of clinical trials are now underway for new forms of the mRNA vaccine—targeting everything from malaria to Zika, herpes, and cytomegalovirus. Last month, Moderna—which was founded in 2014 to explore the potential of mRNA—announced it had started Phase I clinical trials for two mRNA-based HIV vaccines. “The timeline for what can be achieved using the mRNA platform is so much better,” says Carl Dieffenbach, director of the Division of AIDS at the US National Institutes of Health, who is overseeing those trials. There was some work on mRNA happening before the pandemic—Moderna had spent years on the lipid envelope that encases the strand of mRNA in the vaccine, for instance. “Like all overnight successes, mRNA has been in development for a long time,” says Richard Hatchett of the Coalition for Epidemic Preparedness Innovations (CEPI). The US Biomedical Advanced Research and Development Authority invested in an mRNA vaccine for Zika in 2016, but “the urgency sort of trailed off” as the outbreak subsided, Hatchett says. There had also been tentative attempts to develop mRNA platforms for other coronaviruses, such as MERS, work that proved crucial when Covid broke out. Moderna was able to tweak its MERS vaccine for the new disease, meaning its Covid vaccine entered clinical trials just 66 days after SARS-CoV-2’s genetic sequence was published. It’s true that mRNA vaccines would probably have come to market eventually, but they were on what Dieffenbach calls “a leisurely stroll.” Covid “pressure-tested” them—advancing their emergence by years or decades. Karikó remembers organizing the first mRNA conference in 2013 and says that nobody in attendance would have expected an FDA-approved product less than 10 years later. “Because of the success against Covid, we’re going to see tremendous investment, and we’re going to learn just how flexible it is and how finely we can target,” says Hatchett. One of mRNA’s strengths is its “remarkable agility,” as Hatchett puts it. Its only raw ingredients are the four nucleotides that form the “letters” of the RNA sequence, so it can be designed and made pretty rapidly. “Biological manufacturing is very hard and temperamental and has been difficult to introduce in many environments. It’s taken India decades to build up the vaccine manufacturing capability they have,” says Hatchett. “It may be easier for countries to develop an mRNA production capacity than traditional biological manufacturing capability.” Developing countries could, Hatchett suggests, leapfrog over traditional vaccine-manufacturing processes and go straight to mRNA—mRNA plants are already being planned in countries across Africa and Asia. After Covid, they could be quickly repurposed to create vaccines for other diseases—all you need to do is change the order of the bases in the mRNA to give the body a new set of instructions. There are also far fewer concerns about purity or contamination than with traditional vaccines—the body quickly translates, expresses, and breaks down the strand of mRNA. “mRNA is completely interchangeable,” says Jackie Miller, senior vice president for infectious diseases at Moderna. “What changes between the different vaccines is the DNA template that we utilize to synthesize the messenger RNA, but across all of our vaccine portfolio, we’re using the same lipid nanoparticle.” [@50% MORE AT LINK] [link to www.wired.com (secure)] |
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TerraFirma's Esoterrorist
User ID: 83924675 United States 11/05/2022 12:13 PM Report Abusive Post Report Copyright Violation | Re: For mRNA, Covid Vaccines Are Just the Beginning "Keep a weather eye to the chart on high and go home another way"
–James Taylor Never Die Young
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Anonymous Coward User ID: 18739626 United States 11/05/2022 12:17 PM Report Abusive Post Report Copyright Violation | Re: For mRNA, Covid Vaccines Are Just the Beginning will never take a vaccine of any kind ever again
fuck the medical establishment to hell |
Anonymous Coward User ID: 84599932 11/05/2022 12:17 PM Report Abusive Post Report Copyright Violation | Re: For mRNA, Covid Vaccines Are Just the Beginning mRNA has potential for future treatments of things like cancer. Imagine creating mRNA that can cause cancer cells and only cancer cells to self destruct? That would be a lot safer than chemo |
Anonymous Coward User ID: 84599932 11/05/2022 12:18 PM Report Abusive Post Report Copyright Violation | Re: For mRNA, Covid Vaccines Are Just the Beginning mRNA has potential for future treatments of things like cancer. Imagine creating mRNA that can cause cancer cells and only cancer cells to self destruct? That would be a lot safer than chemo
Quoting: Anonymous Coward 84599932 I’m talking about future potential mRNA technology, but current ‘vaccines’ |
Anonymous Coward User ID: 78835424 11/05/2022 12:19 PM Report Abusive Post Report Copyright Violation | Re: For mRNA, Covid Vaccines Are Just the Beginning (((vaccines))) are the work of holocaust survivors |
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Base12
User ID: 78222180 United States 11/05/2022 12:19 PM Report Abusive Post Report Copyright Violation | Re: For mRNA, Covid Vaccines Are Just the Beginning |
Anonymous Coward User ID: 84599932 11/05/2022 12:19 PM Report Abusive Post Report Copyright Violation | Re: For mRNA, Covid Vaccines Are Just the Beginning mRNA has potential for future treatments of things like cancer. Imagine creating mRNA that can cause cancer cells and only cancer cells to self destruct? That would be a lot safer than chemo
Quoting: Anonymous Coward 84599932 I’m talking about future potential mRNA technology, but current ‘vaccines’ Quoting: Anonymous Coward 84599932 *not current vaccines. I need another coffee this morning. Or is it a conspiracy that caffeine is the most popular drug in the world? |
Anonymous Coward User ID: 78691426 Germany 11/05/2022 12:20 PM Report Abusive Post Report Copyright Violation | Re: For mRNA, Covid Vaccines Are Just the Beginning |
Mojo Rysen
User ID: 84011440 United States 11/05/2022 12:21 PM Report Abusive Post Report Copyright Violation | Re: For mRNA, Covid Vaccines Are Just the Beginning "Over the past 18 months, mRNA technology has been injected into billions of arms and has helped slow the devastating impact of the pandemic." FUCK YOU TARD. You're a FUCKING IDIOT. Mojo Rysen |
Anonymous Coward User ID: 84518502 United States 11/05/2022 12:22 PM Report Abusive Post Report Copyright Violation | Re: For mRNA, Covid Vaccines Are Just the Beginning Who made this legal?
Quoting: Base12 They same people who make everything they do "legal" |
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Anonymous Coward User ID: 84649989 United States 11/05/2022 12:22 PM Report Abusive Post Report Copyright Violation | Re: For mRNA, Covid Vaccines Are Just the Beginning mRNA has potential for future treatments of things like cancer. Imagine creating mRNA that can cause cancer cells and only cancer cells to self destruct? That would be a lot safer than chemo
Quoting: Anonymous Coward 84599932 yeah, it cures your brain cancer and gives you liver cancer. . |
Anonymous Coward User ID: 84649501 Germany 11/05/2022 12:23 PM Report Abusive Post Report Copyright Violation | Re: For mRNA, Covid Vaccines Are Just the Beginning "Over the past 18 months, mRNA technology has been injected into billions of arms and has helped slow the devastating impact of the pandemic." FUCK YOU TARD. You're a FUCKING IDIOT. Quoting: Mojo Rysen back to your cave troll pharmashill |
Anonymous Coward User ID: 84620011 Germany 11/05/2022 12:26 PM Report Abusive Post Report Copyright Violation | Re: For mRNA, Covid Vaccines Are Just the Beginning mRNA has potential for future treatments of things like cancer. Imagine creating mRNA that can cause cancer cells and only cancer cells to self destruct? That would be a lot safer than chemo
Quoting: Anonymous Coward 84599932 The problem with such a powerful technology is that people (scientists) will start to fuck around until they find out. In the course of that fucking around bad stuff can happen. Much like nuclear power I don't think humanity as a whole is not developed and wise enough to fuck around with such stuff. |
Anonymous Coward (OP) User ID: 84645381 United States 11/05/2022 12:28 PM Report Abusive Post Report Copyright Violation | Re: For mRNA, Covid Vaccines Are Just the Beginning "Over the past 18 months, mRNA technology has been injected into billions of arms and has helped slow the devastating impact of the pandemic." FUCK YOU TARD. You're a FUCKING IDIOT. Quoting: Mojo Rysen back to your cave troll pharmashill Quoting: Anonymous Coward 84649501 He was addressing the article, not agreeing with it. They want to make it into a powder or an airasol too. |
Anonymous Coward User ID: 84232115 United States 11/05/2022 12:28 PM Report Abusive Post Report Copyright Violation | Re: For mRNA, Covid Vaccines Are Just the Beginning Who made this legal?
Quoting: Base12 Money made this legal. Greed made this legal. The whore of Babylon made this legal. |
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Anonymous Coward (OP) User ID: 84645381 United States 11/05/2022 12:31 PM Report Abusive Post Report Copyright Violation | Re: For mRNA, Covid Vaccines Are Just the Beginning OP, quit being lazy, you do the hard work and digest what is being said, this is your presentation to us. Anybody can throw up a wall of text.
Quoting: Anonymous Coward 72827042 I am just submitting it for people to see so they can evaluate on their own. Besides, I already read it. I want others to read it. Not all posters make a thread all about them. It's the content being shared so other can know about it too, that matters. I don't need to hold your hand through the process. I have other things to do today. I just want people to be aware of what is going on. |
Wobblin Goblin
User ID: 81252795 United States 11/05/2022 12:31 PM
Report Abusive Post Report Copyright Violation | Re: For mRNA, Covid Vaccines Are Just the Beginning will never take a vaccine of any kind ever again
fuck the medical establishment to hell
Quoting: Anonymous Coward 18739626 AGREED! After all that has happened, I don't trust ANY more injections of any sort. |
Anonymous Coward User ID: 78131002 United States 11/05/2022 12:32 PM Report Abusive Post Report Copyright Violation | Re: For mRNA, Covid Vaccines Are Just the Beginning Any Human that takes any Shots, or drugs from the Medical Establishment from here forward, deserves everything they are about to have happen to them.
It's 100% evident that the Medical field has been instructed to Kill the World Populations. |
Let Freedom Ring 365
User ID: 84116678 United States 11/05/2022 12:35 PM
Report Abusive Post Report Copyright Violation | Re: For mRNA, Covid Vaccines Are Just the Beginning You are the creator of your own master plan... Make it a good one.
Wake the fuk up and be ready... This is absolutely no time to be stupid!
“If you want to find the secrets of the universe, think in terms of energy, frequency and vibration.” - Nikola Tesla |
Anonymous Coward User ID: 84146961 United States 11/05/2022 12:36 PM Report Abusive Post Report Copyright Violation | Re: For mRNA, Covid Vaccines Are Just the Beginning there was no pandemic
just a gimmick to sell drugs |
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Anonymous Coward User ID: 83899792 United States 11/05/2022 12:39 PM Report Abusive Post Report Copyright Violation | Re: For mRNA, Covid Vaccines Are Just the Beginning there was no pandemic
just a gimmick to sell drugs
Quoting: Anonymous Coward 84146961 ^^this^^ |
Anonymous Coward User ID: 81613033 United States 11/05/2022 12:43 PM Report Abusive Post Report Copyright Violation | Re: For mRNA, Covid Vaccines Are Just the Beginning will never take a vaccine of any kind ever again
fuck the medical establishment to hell
Quoting: Anonymous Coward 18739626 Ditto Who the fuck would trust these psychopaths ever again? |
Anonymous Coward User ID: 71110708 South Africa 11/05/2022 12:43 PM Report Abusive Post Report Copyright Violation | Re: For mRNA, Covid Vaccines Are Just the Beginning mRNA has potential for future treatments of things like cancer. Imagine creating mRNA that can cause cancer cells and only cancer cells to self destruct? That would be a lot safer than chemo
Quoting: Anonymous Coward 84599932 Erm, I'm not imagining all the rampant cancer cases that were in remission until the mrna jab kickstarted them. |
scimitar
User ID: 77644396 United States 11/05/2022 12:45 PM
Report Abusive Post Report Copyright Violation | Re: For mRNA, Covid Vaccines Are Just the Beginning Any Human that takes any Shots, or drugs from the Medical Establishment from here forward, deserves everything they are about to have happen to them.
It's 100% evident that the Medical field has been instructed to Kill the World Populations.
Quoting: Tick Tock From a top level I agree... Although I am certain there are many doctors in the world who are not guilty of that crime, the real question would be who could you trust? As with all technology it can be used for good or evil. Last Edited by scimitar on 11/05/2022 12:46 PMOminous regressions One Truth... many realities |
SqueakyOne
User ID: 81769346 United States 11/05/2022 12:50 PM
Report Abusive Post Report Copyright Violation | Re: For mRNA, Covid Vaccines Are Just the Beginning Repented not of their pharmakeia- hmmm we saw this somewhere Last Edited by SqueakyOne on 11/05/2022 12:51 PM |
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Anonymous Coward (OP) User ID: 84645381 United States 11/05/2022 12:52 PM Report Abusive Post Report Copyright Violation | Re: For mRNA, Covid Vaccines Are Just the Beginning "She had envisioned the technology being used to treat those recovering from heart attacks and strokes."
Myocarditis anyone..... |
Anonymous Coward User ID: 83923878 United States 11/05/2022 12:54 PM Report Abusive Post Report Copyright Violation | Re: For mRNA, Covid Vaccines Are Just the Beginning mRNA has potential for future treatments of things like cancer. Imagine creating mRNA that can cause cancer cells and only cancer cells to self destruct? That would be a lot safer than chemo
Quoting: Anonymous Coward 84599932 Imagine creating mRNA that causes cancer and then claiming to be creating mRNA that cures cancer. There you go, corrected it for you. |
Anonymous Coward (OP) User ID: 84645381 United States 11/05/2022 01:00 PM Report Abusive Post Report Copyright Violation | Re: For mRNA, Covid Vaccines Are Just the Beginning mRNA has potential for future treatments of things like cancer. Imagine creating mRNA that can cause cancer cells and only cancer cells to self destruct? That would be a lot safer than chemo
Quoting: Anonymous Coward 84599932 The problem with such a powerful technology is that people (scientists) will start to fuck around until they find out. In the course of that fucking around bad stuff can happen. Much like nuclear power I don't think humanity as a whole is not developed and wise enough to fuck around with such stuff. Quoting: Anonymous Coward 84620011 I think you stated the whole premise of why God told Adam not to eat of the tree of knowledge of good and evil. Eve took ate and then gave to Adam. I wonder how things would have gone if Adam had refused? God probably would have dropped a tree on her and made another wife for him. heh. |
Anonymous Coward User ID: 84647882 Canada 11/05/2022 01:03 PM Report Abusive Post Report Copyright Violation | Re: For mRNA, Covid Vaccines Are Just the Beginning will never take a vaccine of any kind ever again
fuck the medical establishment to hell
Quoting: Anonymous Coward 18739626 Ditto Who the fuck would trust these psychopaths ever again? Quoting: Anonymous Coward 81613033 I know: I have a dead molar as I type (broken in 1/2 and loose that just won't fall off) and I don't trust dentists anymore after a root canal where they illicitly drill TWO teeth instead of just the one molar (another one) and the white composite materials fall off. I patch them up myself. Who knows what the novocaine etc will have in it! |
MAGA Republican BrainGuy
White heteropatriarchal supremacist chemophob
User ID: 78051722 United States 11/05/2022 01:06 PM
Report Abusive Post Report Copyright Violation | Re: For mRNA, Covid Vaccines Are Just the Beginning Quoting: TerraFirma's Esoterrorist --------------- Don't care. Still voting Trump! ---------- |
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