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Autoimmune hepatitis after COVID-19 vaccine - more than a coincidence"

 
Anonymous Coward
User ID: 23415018
United States
04/27/2022 03:04 AM
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Autoimmune hepatitis after COVID-19 vaccine - more than a coincidence"
"Abstract
The COVID-19 pandemic is still raging across the world and vaccination is expected to lead us out of this pandemic. Although the efficacy of the vaccines is beyond doubt, safety still remains a concern. We report a case of a 65-year-old woman who experienced acute severe autoimmune hepatitis two weeks after receiving the first dose of Moderna-COVID-19 vaccine. Serum immunoglobulin G was elevated and antinuclear antibody was positive (1:100, speckled pattern). Liver histology showed a marked expansion of the portal tracts, severe interface hepatitis and multiple confluent foci of lobular necrosis. She started treatment with prednisolone, with a favorable clinical and analytical evolution. Some recent reports have been suggested that COVID-19 vaccination can lead to the development of autoimmune diseases. It is speculated that the vaccine can disturb self-tolerance and trigger autoimmune responses through cross-reactivity with host cells. Therefore, healthcare providers must remain vigilant during mass COVID-19 vaccination.
Anonymous Coward (OP)
User ID: 23415018
United States
04/27/2022 03:05 AM
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Re: Autoimmune hepatitis after COVID-19 vaccine - more than a coincidence"
"Abstract
The COVID-19 pandemic is still raging across the world and vaccination is expected to lead us out of this pandemic. Although the efficacy of the vaccines is beyond doubt, safety still remains a concern. We report a case of a 65-year-old woman who experienced acute severe autoimmune hepatitis two weeks after receiving the first dose of Moderna-COVID-19 vaccine. Serum immunoglobulin G was elevated and antinuclear antibody was positive (1:100, speckled pattern). Liver histology showed a marked expansion of the portal tracts, severe interface hepatitis and multiple confluent foci of lobular necrosis. She started treatment with prednisolone, with a favorable clinical and analytical evolution. Some recent reports have been suggested that COVID-19 vaccination can lead to the development of autoimmune diseases. It is speculated that the vaccine can disturb self-tolerance and trigger autoimmune responses through cross-reactivity with host cells. Therefore, healthcare providers must remain vigilant during mass COVID-19 vaccination.
 Quoting: Anonymous Coward 23415018


[link to pubmed.ncbi.nlm.nih.gov (secure)]
Anonymous Coward (OP)
User ID: 23415018
United States
04/27/2022 03:07 AM
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Re: Autoimmune hepatitis after COVID-19 vaccine - more than a coincidence"
Have some of them decided that it's a_nat_security threat to admit the truth about such matters?
Anonymous Coward
User ID: 16361383
Denmark
04/27/2022 03:10 AM
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Re: Autoimmune hepatitis after COVID-19 vaccine - more than a coincidence"
500 people in 3 billion maybe its not the vax
Anonymous Coward
User ID: 82821851
Cambodia
04/27/2022 03:30 AM
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Re: Autoimmune hepatitis after COVID-19 vaccine - more than a coincidence"
another one :

[link to www.sciencedirect.com (secure)]

Lay summary
Liver inflammation is observed during SARS-CoV-2 infection but can also occur in some individuals after vaccination and shares some typical features with autoimmune liver disease. In this report, we show that highly activated T cells accumulate and are evenly distributed in the different areas of the liver in a patient with liver inflammation following SARS-CoV-2 vaccination. Moreover, within these liver infiltrating T cells, we observed an enrichment of T cells that are reactive to SARS-CoV-2, suggesting that these vaccine-induced cells can contribute to the liver inflammation in this context.





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