What's the definition of observer-blind study during vaccination trials?

In this document of a similar study, the same term is used and explained in more detail. Question solved:

quoting [link to cdn.pfizer.com (secure)]

In this observer blinded study, the study staff receiving, storing, dispensing, preparing, and administering the study interventions will be unblinded.

All other study and site personnel, including the investigator, investigator staff, and participants, will be blinded to study intervention assignments.

Because the BNT162 RNA-based COVID-19 vaccine candidates and placebo are different in physical appearance, the study intervention syringes will be administered in a manner that prevents the study participants from identifying the study intervention type based on its appearance.

The responsibility of the unblinded dispenser and administrator must be assigned to an individual or individuals who will not participate in the evaluation of any study participants.

That is interesting because they are basically saying that the deathvaxx is appreciably different looking than something like saline (or whatever)?

Or that the saline couldn't be reasonably modified to appear like the deathvaxx? (after developing mRNA nanoparticles they can't figure out how to add coloring etc???)

Or that a scheme couldn't be made to always have two equally large sized groups of administrators always give one or the other and be isolated from one another?

Sounds like more pfizer shenanigans like when they completely unblinded the study after a few months and let the unvaxxed go and take real vaxxes so that no long term control group was left.

Cov, the final frontier.

Yes, that's my interpretation: Either because of different vials or because of difference in colors of the liquid. The dispenser or administrator, i.e. the person filling the syringe from the vial would technically be able to distinguish between them.

Unfortunately they don't specify clearer why the injection dispenser cannot be blinded.

Last Edited by McKracken on 01/25/2022 01:48 AM

I'll bet they can't.