Vaccines in your salad? Scientists growing medicine-filled plants to replace injections

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"RIVERSIDE, Calif. — Vaccinations can be a controversial subject for many people, especially when it comes to injections. So what if you could replace your next shot with a salad instead? Researchers at the University of California-Riverside are working on a way to grow edible plants that carry the same medication as an mRNA vaccine.

The COVID-19 vaccine is one of the many inoculations which use messenger RNA (mRNA) technology to defeat viruses. They work by teaching cells from the immune system to recognize and attack a certain infectious disease. Unfortunately, mRNA vaccines have to stay in cold storage until use or they lose stability. The UC-Riverside team says if they’re successful, the public could eat plant-based mRNA vaccines — which could also survive at room temperature.

Thanks to a $500,000 grant from the National Science Foundation, researchers are now looking accomplish three goals. First, the team will try to successfully deliver DNA containing mRNA vaccines into plant cells, where they can replicate. Next, the study authors want to show that plants can actually produce enough mRNA to replace a traditional injection. Finally, the team will need to determine the right dosage people will need to eat to properly replace vaccinations.

“Ideally, a single plant would produce enough mRNA to vaccinate a single person,” says Juan Pablo Giraldo, an associate professor in UCR’s Department of Botany and Plant Sciences, in a university release.

“We are testing this approach with spinach and lettuce and have long-term goals of people growing it in their own gardens,” Giraldo adds. “Farmers could also eventually grow entire fields of it.”"