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CLONED HUMAN EMBRYO'S FROM A MAN'S SKIN CELLS---WELCOME TO THE ISLAND.

 
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01/18/2008 05:44 AM
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CLONED HUMAN EMBRYO'S FROM A MAN'S SKIN CELLS---WELCOME TO THE ISLAND.
First cloned human embryo created from skin cell
14:37 17 January 2008
NewScientist.com news service
Andy Coghlan

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Stemagen
A cloned human embryo has been produced for the first time from a man's skin cell, raising the prospect that such embryos could be made to provide stem cells tailored to any patient.

Only one cloned human embryo has been made before, reported by a team at Newcastle University, UK, in 2005. But it was made by cloning human embryonic stem cells that are not routinely available from patients, and so would not be practical.

The embryo newly created from a skin cell potentially gets round this problem. The ultimate aim is to make temporary embryos from which human embryonic stem cells (hESCs) could be extracted – these are the cells in embryos from which all tissues of the body originate.

Once obtained, these could be turned into tissue for treating the patient without any fear of rejection, as the cells originated from the patient.

Emptied eggs
But Stemagen, the company in La Jolla, California, US, which reported the breakthrough on Thursday, says its researchers did not manage to extract any stem cells from their cloned embryos.

"We are currently pursuing the generation of embryonic stem cell lines from embryos generated using [our] protocols," say the researchers.

Starting with skin cells donated by two men and eggs donated by three young women undergoing fertility treatment, they made each embryo by fusing the nuclear DNA from a skin cell with an egg emptied of its own nuclear DNA.

Of the 21 embryos created through this process, called somatic cell nuclear transfer (SCNT), five survived and grew into blastocysts containing between 40 and 72 cells.

Proof of cloning
And of these five, three turned out to contain DNA from the skin cell of the man, proving it had been reprogrammed to become an embryo.

Even more crucial, one of these three was proved to contain mitochondrial DNA from the woman who donated the egg, the only remaining female DNA in the clone. This is taken to provide definitive evidence that the technique worked.

Mitochondrial DNA is found in the egg lining, and is vital for cloning because it contains the instructions for reprogramming the skin cell back to an embryo. So finding the male nuclear DNA and the female mitochondrial DNA in the same embryo proved it was cloned.

"This study demonstrates, for the first time, that SCNT can be utilised to generate cloned human blastocysts using differentiated adult donor nuclei remodelled and reprogrammed by human oocytes," say the researchers.

But they acknowledge that the most important objective remains to prove that such embryos yield hESCs. "The data we present are not in any way the final word on the topic," says team leader, Andrew French.

DNA fingerprinting
A team led by Woo Suk Hwang at Seoul National University in South Korea claimed to have produced hESCs in this way, but the research turned out to be fraudulent.

To avoid similar accusations, the Stemagen team went to great lengths to have their findings validated using DNA fingerprinting.

"The results verified, for the first time through DNA and mitochondrial DNA fingerprinting, that of the five blastocysts, only one had the donor cell genomic DNA and the oocyte mitochondrial DNA," says Miodrag Stojkovic at the Prince Felipe Investigation Centre in Valencia, Spain, in commentary accompanying the paper in the journal Stem Cells.

Stojkovic, a member of the Newcastle team that produced the previous cloned human embryo, says the breakthrough is a key advance towards patient-specific treatments. "Although these results are preliminary, since no stem cell lines have been derived from the cloned embryos, this may now be attempted."

Hybrid clones
In the UK, meanwhile, two research teams received licences from the government's Human Fertilisation and Embryology Authority to try reprogramming human skin and other adult cells by fusing them with cow or rabbit eggs.

"Cow eggs seem to be every bit as good at doing this job as human eggs, so it makes sense to use them since they are much more readily available," says Lyle Armstrong of the International Centre for Life at the University of Newcastle upon Tyne.

The aim is to just use them as a scientific tool to find out how to reprogramme cells without using human eggs, which are in short supply.

Armstrong, also part of the Newcastle team which produced the only other cloned human embryo, commends the Stemagen breakthrough. "It's very significant that they've done it with skin cells," he says.

But Armstrong feels the Stemagen breakthrough will be important for research, not treatment, because hundreds of thousands of eggs would be needed for the technique to be useful clinically.

"I think the tiny number of eggs from women would preclude medical use," he told New Scientist. "Our ultimate aim is to replicate the reprogramming the egg does, but without the egg," he says.

A team led by Shinyu Yamanaka of Kyoto University reported doing precisely this last November, reprogramming skin cells by exposing them to four natural growth factors. But the technique, which generated "induced pluripotent stem cells" similar to hESCs, required viruses that would make it too dangerous to apply clinically.

The other team receiving an HFEA licence to try making animal-human "cybrids" was led by Stephen Minger of King's College London, UK.

Journal reference: Stem Cells (DOI: 10.1634/stemcells.2007-0252)
Anonymous Coward
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01/18/2008 05:47 AM
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Re: CLONED HUMAN EMBRYO'S FROM A MAN'S SKIN CELLS---WELCOME TO THE ISLAND.
I'll go to the "Island"....As long as I'm able to drill Scarlett Johansen...
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01/18/2008 05:49 AM
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Re: CLONED HUMAN EMBRYO'S FROM A MAN'S SKIN CELLS---WELCOME TO THE ISLAND.
I'll go to the "Island"....As long as I'm able to drill Scarlett Johansen...
 Quoting: Anonymous Coward 356215


SO YOU'D SELL YOUR SOUL FOR SEX?

A WONDER THE WORLD IS THE WAY IT IS!!! ;)
Anonymous Coward
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01/18/2008 05:52 AM
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Re: CLONED HUMAN EMBRYO'S FROM A MAN'S SKIN CELLS---WELCOME TO THE ISLAND.
I said go and drill, not sell my soul. Horny....yes. Insane...no.
Anonymous Coward
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01/18/2008 05:56 AM
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Re: CLONED HUMAN EMBRYO'S FROM A MAN'S SKIN CELLS---WELCOME TO THE ISLAND.
wow

people this is not good!!!

now I see why the end is on us!

ice
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01/18/2008 05:59 AM
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Re: CLONED HUMAN EMBRYO'S FROM A MAN'S SKIN CELLS---WELCOME TO THE ISLAND.
wow

people this is not good!!!

now I see why the end is on us!

ice
 Quoting: Ice


EXACTLY...NOW THAT THEY ADMIT IT'S BEEN DONE WE CAN PRETTY MUCH BE SURE IT'S OLD TECHNOLOGY ALREADY AND THEY ARE FAR MORE ADVANCED THAN THIS STAGE ALREADY.
1
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01/18/2008 06:07 AM
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Re: CLONED HUMAN EMBRYO'S FROM A MAN'S SKIN CELLS---WELCOME TO THE ISLAND.
REMEMBER,,,,the Zeta's said that they have been proppogating the hybrid human......and then on unknowncountry.com this guy talks about going to the south pole and he and team members speculate that the ice cube project is an alien cloning project and that millions of them will be released into the population of the planet to start their agenda.....things really do seem to be connecting the dots.....and they are very VERY interesting....at this time in our history do not poopoo anything and blow it off.
meras
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01/18/2008 06:37 AM
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Re: CLONED HUMAN EMBRYO'S FROM A MAN'S SKIN CELLS---WELCOME TO THE ISLAND.
Now steady on there, when scientific fraud takes place in the biosciences it is soon uncovered by people working in the related field unlike the cosmologists who can make claims which are hard to verify.

Stem cells offer the hope of treatment for conditions that would otherwise be untreatable:- [link to news.bbc.co.uk]
<> <> (OP)
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01/18/2008 06:46 AM
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Re: CLONED HUMAN EMBRYO'S FROM A MAN'S SKIN CELLS---WELCOME TO THE ISLAND.
Now steady on there, when scientific fraud takes place in the biosciences it is soon uncovered by people working in the related field unlike the cosmologists who can make claims which are hard to verify.

Stem cells offer the hope of treatment for conditions that would otherwise be untreatable:- [link to news.bbc.co.uk]
 Quoting: meras 357462


STEM CELL RESEARCH IS THE COVER...SOULESS MEAT SUITS ARE THE END PRODUCT.

I THINK THEY ARE CALLED THE GOLUM.
Anonymous Coward
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01/18/2008 06:53 AM
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Re: CLONED HUMAN EMBRYO'S FROM A MAN'S SKIN CELLS---WELCOME TO THE ISLAND.
If the corrupt media is actually telling us this, just imagine what they aren´t telling us...and for how long cloning has really been around...
meras
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01/18/2008 06:54 AM
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Re: CLONED HUMAN EMBRYO'S FROM A MAN'S SKIN CELLS---WELCOME TO THE ISLAND.
Most researchers have strong ethics and are intent on the good.

The true reality is good because we are an integral part of the Creator and the Creator is pure love.

The Earth is a school and we are the pupils we don't need to experience the negative if we can comprehend it.
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01/18/2008 07:42 AM
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Re: CLONED HUMAN EMBRYO'S FROM A MAN'S SKIN CELLS---WELCOME TO THE ISLAND.
Most researchers have strong ethics and are intent on the good.

The true reality is good because we are an integral part of the Creator and the Creator is pure love.

The Earth is a school and we are the pupils we don't need to experience the negative if we can comprehend it.
 Quoting: meras 357462


I AGREE WITH YOU...HOWEVER THERE IS A VERY SMALL PERCENTAGE OF US THAT REACH THAT LEVEL OF AWARENESS AND UNFORTUNATELY THE MAJORITY OF THE EARTH WILL EXPERIENCE NEGATIVE IN THE EXTREME.
Anonymous Coward
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01/18/2008 07:45 AM
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Re: CLONED HUMAN EMBRYO'S FROM A MAN'S SKIN CELLS---WELCOME TO THE ISLAND.
Here's the link for the OP's post

[link to www.newscientist.com]
meras
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01/18/2008 08:21 AM
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Re: CLONED HUMAN EMBRYO'S FROM A MAN'S SKIN CELLS---WELCOME TO THE ISLAND.
We do not need to seek the negative we do not need to give it life with our life-energy our thoughts.
interest bump
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01/18/2008 09:47 AM
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Re: CLONED HUMAN EMBRYO'S FROM A MAN'S SKIN CELLS---WELCOME TO THE ISLAND.
book
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01/18/2008 12:13 PM
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Re: CLONED HUMAN EMBRYO'S FROM A MAN'S SKIN CELLS---WELCOME TO THE ISLAND.
bushtard CLONES GONE WILD
-=JezaBella=-

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01/18/2008 01:01 PM
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Re: CLONED HUMAN EMBRYO'S FROM A MAN'S SKIN CELLS---WELCOME TO THE ISLAND.
Man has crossed the line........
"Be who you are and say what you feel because those who mind don't matter and those who matter don't mind."
~ Dr. Seuss
Anonymous Coward
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01/18/2008 01:03 PM
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Re: CLONED HUMAN EMBRYO'S FROM A MAN'S SKIN CELLS---WELCOME TO THE ISLAND.
This was posted yesterday!!!
Anonymous Coward (OP)
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01/18/2008 04:23 PM
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Re: CLONED HUMAN EMBRYO'S FROM A MAN'S SKIN CELLS---WELCOME TO THE ISLAND.
This was posted yesterday!!!
 Quoting: Anonymous Coward 357606


ACTUALLY AT 5:44 AM THIS MORNING,BUT THANKS FOR PAYIN ATTENTION;)





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