American Journal of Cancer Research, Feb. 2018: "Ivermectin has PROVEN anti-tumor activity" | |
Anonymous Coward User ID: 1372943 United States 09/08/2021 05:01 PM Report Abusive Post Report Copyright Violation | Ivermectin showed massive positive results on Leukemia, Breast, Colon, Ovarian, Glioma and Glioblastoma Cancers: Quoting: Et Sano "Conclusions: The recognition that drug repositioning is a clever opportunity to accelerate the development of cancer drugs is increasing. So far, at least 235 clinically-approved, non-cancer drugs have proven antitumor activity either in vitro, in vivo, or even clinically. Among these, ivermectin, an antiparasitic compound of wide use in veterinary and human medicine, is clearly a strong candidate for repositioning, based on the fact that i) it is very safe, causing almost no side-effects other than those caused by the immune and inflammatory responses against the parasite in infected patients, and ii) it has proven antitumor activity in preclinical studies. On the other hand, it is now evident that the use of very selective 'unitargeted' drugs is commonly associated to early development of resistance by cancer cells, hence the use of 'dirty' or 'multitargeted' drugs is important to explore. In this sense, ivermectin has this potential as it modulates several targets such as the multidrug resistance protein (MDR), the Akt/mTOR and WNT-TCF pathways, the purinergic receptors, the PAK-1 protein, certain cancer-related epigenetic deregulators such as SIN3A and SIN3B, RNA helicase activity, while stimulates chloride channel receptors leading to cell hyperpolarization, and down-regulates stemness genes to preferentially target cancer stem-cell like population, at least in breast cancer. Importantly, the in vitro and in vivo antitumor activities of ivermectin are achieved at concentrations that can be clinically reachable based on the human pharmacokinetic studies done in healthy and parasited patients. Thus, existing information on ivermectin could allow its rapid move into clinical trials for cancer patients." [link to www.ncbi.nlm.nih.gov (secure)] :mred19: :trickydick19: We could cure cancer tomorrow if we wanted but its not profitable. |
Anonymous Coward User ID: 80847587 United States 09/08/2021 05:17 PM Report Abusive Post Report Copyright Violation | Ivermectin showed massive positive results on Leukemia, Breast, Colon, Ovarian, Glioma and Glioblastoma Cancers: Quoting: Et Sano "Conclusions: The recognition that drug repositioning is a clever opportunity to accelerate the development of cancer drugs is increasing. So far, at least 235 clinically-approved, non-cancer drugs have proven antitumor activity either in vitro, in vivo, or even clinically. Among these, ivermectin, an antiparasitic compound of wide use in veterinary and human medicine, is clearly a strong candidate for repositioning, based on the fact that i) it is very safe, causing almost no side-effects other than those caused by the immune and inflammatory responses against the parasite in infected patients, and ii) it has proven antitumor activity in preclinical studies. On the other hand, it is now evident that the use of very selective 'unitargeted' drugs is commonly associated to early development of resistance by cancer cells, hence the use of 'dirty' or 'multitargeted' drugs is important to explore. In this sense, ivermectin has this potential as it modulates several targets such as the multidrug resistance protein (MDR), the Akt/mTOR and WNT-TCF pathways, the purinergic receptors, the PAK-1 protein, certain cancer-related epigenetic deregulators such as SIN3A and SIN3B, RNA helicase activity, while stimulates chloride channel receptors leading to cell hyperpolarization, and down-regulates stemness genes to preferentially target cancer stem-cell like population, at least in breast cancer. Importantly, the in vitro and in vivo antitumor activities of ivermectin are achieved at concentrations that can be clinically reachable based on the human pharmacokinetic studies done in healthy and parasited patients. Thus, existing information on ivermectin could allow its rapid move into clinical trials for cancer patients." [link to www.ncbi.nlm.nih.gov (secure)] :mred19: :trickydick19: We could cure cancer tomorrow if we wanted but its not profitable. Thread: BREAKING: Breast Cancer was Cured in 2011 |
Just Passing Through.....
*MOLON LABE* User ID: 80366167 United States 09/08/2021 05:18 PM Report Abusive Post Report Copyright Violation | Ivermectin showed massive positive results on Leukemia, Breast, Colon, Ovarian, Glioma and Glioblastoma Cancers: Quoting: Et Sano "Conclusions: The recognition that drug repositioning is a clever opportunity to accelerate the development of cancer drugs is increasing. So far, at least 235 clinically-approved, non-cancer drugs have proven antitumor activity either in vitro, in vivo, or even clinically. Among these, ivermectin, an antiparasitic compound of wide use in veterinary and human medicine, is clearly a strong candidate for repositioning, based on the fact that i) it is very safe, causing almost no side-effects other than those caused by the immune and inflammatory responses against the parasite in infected patients, and ii) it has proven antitumor activity in preclinical studies. On the other hand, it is now evident that the use of very selective 'unitargeted' drugs is commonly associated to early development of resistance by cancer cells, hence the use of 'dirty' or 'multitargeted' drugs is important to explore. In this sense, ivermectin has this potential as it modulates several targets such as the multidrug resistance protein (MDR), the Akt/mTOR and WNT-TCF pathways, the purinergic receptors, the PAK-1 protein, certain cancer-related epigenetic deregulators such as SIN3A and SIN3B, RNA helicase activity, while stimulates chloride channel receptors leading to cell hyperpolarization, and down-regulates stemness genes to preferentially target cancer stem-cell like population, at least in breast cancer. Importantly, the in vitro and in vivo antitumor activities of ivermectin are achieved at concentrations that can be clinically reachable based on the human pharmacokinetic studies done in healthy and parasited patients. Thus, existing information on ivermectin could allow its rapid move into clinical trials for cancer patients." [link to www.ncbi.nlm.nih.gov (secure)] :mred19: :trickydick19: We could cure cancer tomorrow if we wanted but its not profitable. Such a shame. I'll be happy to see this current system burn to ashes. Its built on lies, deceit, and immorality. But we can't let Klaus, Rothschild and company get their system in to replace this one. It needs to be a system we all agree on. Rough and tumultuous times ahead. Brace yourselves. "She isn't real.....I can't make her real" "Somewhere between the sacred silence and sleep...Disorder, Disorder, Disorder" "The World is a business Mr Beale..." "You depend on our protection yet you feed us lies from the tablecloth......" ENFJ |
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beeches
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Anonymous Coward User ID: 80802755 Israel 09/09/2021 05:33 AM Report Abusive Post Report Copyright Violation | Ivermectin converts cold tumors hot and synergizes with immune checkpoint blockade for treatment of breast cancer "We show that treatment with the FDA-approved anti-parasitic drug ivermectin induces immunogenic cancer cell death (ICD) and robust T cell infiltration into breast tumors. As an allosteric modulator of the ATP/P2X4/P2X7 axis which operates in both cancer and immune cells..." [link to www.sciencedirect.com] Ivermectin, a potential anticancer drug derived from an antiparasitic drug |
Anonymous Coward User ID: 80857581 United States 09/11/2021 04:39 PM Report Abusive Post Report Copyright Violation | [link to www.nature.com (secure)] Quoting: Anonymous Coward 80802755 Ivermectin converts cold tumors hot and synergizes with immune checkpoint blockade for treatment of breast cancer "We show that treatment with the FDA-approved anti-parasitic drug ivermectin induces immunogenic cancer cell death (ICD) and robust T cell infiltration into breast tumors. As an allosteric modulator of the ATP/P2X4/P2X7 axis which operates in both cancer and immune cells..." [link to www.sciencedirect.com] Ivermectin, a potential anticancer drug derived from an antiparasitic drug |