[
link to www.malaysiakini.com (secure)]
We understand that the officials and staffs of MOH are currently overwhelmed with the rising infective and mortality rates of the disease. Our team of researchers are pleased to do the homework pointing to the numerous peer-reviewed scientific studies showing Ivermectin is effective prophylaxis and treatment for Covid-19.
Ivermectin has already been proven to be very safe as it has been used safely and successfully (to treat other tropical diseases) for over 40 years and by four billion people.
We feel that many people are dying every day and getting infected with Covid-19 so unnecessarily.
What have we got to lose in trying out a tried and tested medicine (Ivermectin), which is increasing being used in other countries against Covid-19 and its new variants, that has been proven very safe over and with many recent credible studies around the world confirming that it can reduce the risk of infection against Covid-19 by 88 percent and reduces the mortality rate by 83 percent? There is no official treatment protocol against Covid-19 at the moment.
The studies listed below are randomised controlled trials (RCT), considered the gold standard in evidence-based medicine, peer-reviewed, reproducible, using only Ivermectin and no add-on. Randomisation circumvents the problem with confounding, while the single investigative agent used without the add-on, ie, only Ivermectin, should leave no doubt that any positive result shown is specifically due to the investigative agent.
Most of the RCTs conducted on Ivermectin were of small and medium scale studies. This is not an issue if the trials were well designed and properly conducted, and the results show statistical significance.
Individual doctors who have no ulterior motive or vested interest other than altruistic intent, funded most of the studies. The above points answer the Health DG’s criticism of the Ivermectin studies.
The following RCTs show positive results of Ivermectin on Covid-19:
Babalola et al (2021) in a double-blinded RCT of 62 patients found a significant difference in viral clearance between both the low-dose and high-dose treatment groups and controls.
Chaccour et al (2021) in a small double-blind RCT, randomised 24 patients to Ivermectin and placebo, found statistically significant decreases in viral loads, patient days of anosmia, and patient days with cough.
Elgazzar et al (2020) randomised four treatment groups of 100 hospitalised patients in each group. Groups 1 and 2 were mild to moderate illness patients given either ivermectin plus standard care or hydroxychloroquine plus standard care. Groups 3 and 4 were severely ill patients, either given Ivermectin plus standard care or hydroxychloroquine plus standard care. In both the groups given Ivermectin the rate of disease progression was lower. The mortality rate for the Ivermectin groups was also significantly lower.
Niaee et al (2020) in a randomised placebo-controlled multicenter trial at five hospitals found a dramatic reduction in mortality with Ivermectin use and also improvement in several other clinical parameters.
There are also observational controlled trials (OCT), although not considered the gold standard, nevertheless contribute significantly to the body of scientific knowledge regarding Ivermectin and its therapeutic usefulness. The followings are the OCTs:
Rajter et al (2020) performed a retrospective OCT on 280 consecutively treated patients and compared those treated with Ivermectin to those without and found statistically significant lower mortality among Ivermectin-treated patients. In a subgroup of patients with severe pulmonary disease, mortality was much reduced when treated with Ivermectin.
Khan et al (2020) compared 115 patients treated with Ivermectin to a standard care cohort of 113 patients and found that those receiving Ivermectin became SARs-CoV-2 negative more quickly, fewer developed respiratory distress, and had a shorter hospital stay. There was lower mortality rate in the Ivermectin-treated patients.
Portmann-Baracco et al (2020) in a large OCT that included nearly 1,500 patients reported that in 704 hospitalised patients treated with a single dose of Ivermectin, compared with 704 controls, overall mortality was reduced. For those patients on mechanical ventilation, mortality was also reduced (7).
There are a number of studies showing Ivermectin’s ability to prevent Covid-19. The followings are the prophylaxis studies:
Elgazzar et al (2020) randomised 200 healthcare workers and households who had contact with Covid-19 patients where the intervention group of 100 was given Ivermectin and wore personal protective equipment (PPE), and control of 100 wore PPE. The study found a large and statistically significant reduction in contacts testing positive by RT-PCR when treated with Ivermectin versus control.
Shoumann et al (2021) conducted an RCT involving family members of patients PCR-positive for Covid-19. The Ivermectin group included 203 contacts, while the non-intervention group included 101 contacts. Fifteen in the Ivermectin arm developed Covid-19 compared to 59 in the non-intervention arm after a two weeks follow up. The result also showed a large and statistically significant decrease in Covid-19 symptoms among household members treated with Ivermectin.
Alam et al (2020) conducted a prospective OCT at a hospital with 118 healthcare providers evenly divided into an experimental group receiving a single dose of Ivermectin 12 mg per month for four months, and the control group. Both groups were exposed to Covid-19 positive patients. Results of the symptomatic subjects and tested positive with RT-PCR showed 73.3 percent in the control group were positive for Covid-19 compared to only 6.9 percent in the experimental group.
Hellwig and Maia (2021) studied countries with routine mass drug administration including prophylactic Ivermectin and found that these countries have a significantly lower incidence of Covid-19. This reported correlation is significant to show a possible causal connection.
A few countries in South America provided good information supporting the role of Ivermectin in Covid-19 decreasing transmission rates. Countries like Peru, Brazil and Paraguay initiated the Ivermectin distribution programme for their citizens after their countries were hard hit by the pandemic in April 2020. Some cities started the Ivermectin programme earlier than others. Large decreases in the case count for the cities soon after receiving Ivermectin in comparison to those cities that started the campaign late.
… 50% ….
It has many literature survey here
Last Edited by exiled wine on 06/13/2021 02:27 AM
Taiwan