In conclusion, COVID-19 has a variable prevalence among countries which is lower than expected in malaria-endemic regions. In addition to the possible role of health infrastructure and mitigation tools adopted, the variable distribution of the ACEI/D and the ACE2 (C1173T substitution) polymorphisms could partly explain this variable prevalence. Also, malaria patients develop anti-GPI antibodies which could identify SARS-CoV-2 glycoproteins and consequently play a protective role against COVID-191 or inducing a milder disease pattern. Both hydroxychloroquine (HCQ) and chloroquine (CQ) may have preventive and curative effects against SARS-CoV-2 virus through different mechanisms, however, clinical trials are still investigating the use of these medications as a potential treatment and preventive measures. The lower than expected number of cases detected in Africa suggests that the young age structure may be protective of severe and thus detectable cases. Considering the similarity of symptoms of malaria and COVID-19, clinicians may misdiagnose a malaria case as COVID-19 or vice versa or may overlook the possible coinfection. Finally, the lockdown and restricting movements of health care providers due to the COVID-19 pandemic has disturbed the continuation of malaria control programs such as the distribution of seasonal malaria chemoprevention and insecticide-treated bed nets resulting in more malaria cases and deaths.