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TAKE YOUR JAB! Modified RNA has a direct effect on DNA

 
Nagabonar666
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12/07/2020 05:03 AM
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TAKE YOUR JAB! Modified RNA has a direct effect on DNA
good to know, in case you wonder if the RNA released by the vaccine could possibly modify or regulate your DNA.

New field of research

Normally, epigenetic gene regulation is studied by examining dynamic modifications of DNA and proteins—so-called epigenetic modifications. The modifications can turn genes on or off without changing the underlying genetic code.

Less than 10 years ago, it was discovered that dynamic modifications also exist in RNA and that these have an important role to play in gene regulation


10 years ago scientist already knew that RNA plays a role in gene regulation

[link to phys.org (secure)]
Anonymous Coward
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12/07/2020 05:16 AM
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Re: TAKE YOUR JAB! Modified RNA has a direct effect on DNA
From the article:

“ In areas of DNA where RNA binds to one of the DNA threads in such a way that the complementary DNA thread becomes the sole thread (R-loop structures), the DNA stability will change if RNA is chemically modified by m6A.”

The mRNA in the vaccine has no human sequence such that it will ever bind with human DNA, and in fact does not even enter the nucleus.
Anonymous Coward
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12/07/2020 05:18 AM
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Re: TAKE YOUR JAB! Modified RNA has a direct effect on DNA
The vaccines contain RNA altering mind control technology which allows them to partly control your thoughts remotely by turning a part of your brain's RNA into a radio receiver and 'memory implanter.'

This is why Bill Gates and others are involved. Not because they care about the people. It's all about totalitarian global control ie. the Great Reset and this mind control technology is a planned part of it that they've been working on for decades.

They will be able to subconsciously implant short thoughts and beliefs via over the air radio frequency waves. You will not consciously know it and only think they are your original thoughts.

'trust the government'

'giving total control to government will make us all happy'

'people who resist the government are dangerous terrorists'

'our personal freedoms and rights are too dangerous to the whole of the people'

'do whatever police or military tell you do, without question'

'I do not need or want personal belongings'

'It's best if only the government owns and controls everything'


Do not take the vaccine even if you have to lose your job over it. Once you take the vaccine there is no reversing it.
Anonymous Coward
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12/07/2020 05:19 AM
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Re: TAKE YOUR JAB! Modified RNA has a direct effect on DNA
You do realize mRNA is not RNA?
Anonymous Coward
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12/07/2020 05:22 AM
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Re: TAKE YOUR JAB! Modified RNA has a direct effect on DNA
Who else here expects this to be the BORG shot? With nanotek + dna edit = überslave versus tall regenerated "real" us'es. Nibiru returns for battle in "heaven" autobot vs decepticon.
Anonymous Coward
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12/07/2020 05:28 AM
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Re: TAKE YOUR JAB! Modified RNA has a direct effect on DNA
The vaccines contain RNA altering mind control technology which allows them to partly control your thoughts remotely by turning a part of your brain's RNA into a radio receiver and 'memory implanter.'

This is why Bill Gates and others are involved. Not because they care about the people. It's all about totalitarian global control ie. the Great Reset and this mind control technology is a planned part of it that they've been working on for decades.

They will be able to subconsciously implant short thoughts and beliefs via over the air radio frequency waves. You will not consciously know it and only think they are your original thoughts.

'trust the government'

'giving total control to government will make us all happy'

'people who resist the government are dangerous terrorists'

'our personal freedoms and rights are too dangerous to the whole of the people'

'do whatever police or military tell you do, without question'

'I do not need or want personal belongings'

'It's best if only the government owns and controls everything'


Do not take the vaccine even if you have to lose your job over it. Once you take the vaccine there is no reversing it.
 Quoting: Anonymous Coward 77996433



Yep. What is Bill Gates? He's a computer programmer - one of the world's if not the world's most innovative and influential computer programmers. Why is a computer programmer now so much a key part of this vaccine? Answer: because there's a part of this which is about 'computer programming' your brain.


[link to www.nbcnews.com (secure)]

[link to www.forbes.com (secure)]

[link to www.independent.co.uk (secure)]



They may also be able to read your thoughts with this and that's even scarier.
Levinyl

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12/07/2020 06:27 AM
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Re: TAKE YOUR JAB! Modified RNA has a direct effect on DNA
You do realize mRNA is not RNA?
 Quoting: Anonymous Coward 70883671


Messenger RNA (mRNA) is a subtype of RNA. An mRNA molecule carries a portion of the DNA code to other parts of the cell for processing. mRNA is created during transcription. During the transcription process, a single strand of DNA is decoded by RNA polymerase, and mRNA is synthesized.
scorpio 1986 puerto rico hah
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12/07/2020 06:43 AM
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Re: TAKE YOUR JAB! Modified RNA has a direct effect on DNA
This vaccine is Hitler wetdream, he wished he had all this modern tech at his disposal, Now its the CDS turn it seems.
T2020
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12/07/2020 06:46 AM
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Re: TAKE YOUR JAB! Modified RNA has a direct effect on DNA
Great. Its like this now. They came to innoculate the first responders. After they all died, there was nobody to help US
scorpio 1986 puerto rico hah
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12/07/2020 06:48 AM
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Re: TAKE YOUR JAB! Modified RNA has a direct effect on DNA
This vaccine is Hitler wetdream, he wished he had all this modern tech at his disposal, Now its the CDS turn it seems.
 Quoting: scorpio 1986 puerto rico hah 72575058


correction: CDC
Theobromine The Deplorable

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12/07/2020 06:54 AM

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Re: TAKE YOUR JAB! Modified RNA has a direct effect on DNA
Great. Its like this now. They came to innoculate the first responders. After they all died, there was nobody to help US
 Quoting: T2020 78150776


Dystopian plan or future?

No way to know ...

HINT: Billy Hates is not known for compassion or Fair Play
"What are you helping with all this helping?" Buddhist saying
Franz424

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12/07/2020 07:06 AM
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Re: TAKE YOUR JAB! Modified RNA has a direct effect on DNA
From the article:

“ In areas of DNA where RNA binds to one of the DNA threads in such a way that the complementary DNA thread becomes the sole thread (R-loop structures), the DNA stability will change if RNA is chemically modified by m6A.”

The mRNA in the vaccine has no human sequence such that it will ever bind with human DNA, and in fact does not even enter the nucleus.
 Quoting: Lover_Girl


I'm probably wrong. If the body has an immunological reaction the human's cells can interact with the vaccine. It may have permission to regulate the processes of RNA in certain ways.
We are what we repeatedly do. Excellence, then, is not an act, but a habit. -- Aristotle
Anonymous Coward
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12/07/2020 07:12 AM
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Re: TAKE YOUR JAB! Modified RNA has a direct effect on DNA
They don't even have enough shots to give everyone their first shot.



HOW ARE THEY GOING TO HAVE ENOUGH SHOTS TO GIVE EVERYONE THEIR SECOND SHOT A WEEK LATER?
Anonymous Coward
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12/07/2020 07:21 AM
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Re: TAKE YOUR JAB! Modified RNA has a direct effect on DNA
I read that by 205 if your not in the
‘System’
or hooked to the internet you’ll be locked out
...think about that one no internet
A1 is here programmed now to condition you to depend on internet for everything...yes a net to capture & control your life
Anonymous Coward
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12/07/2020 07:21 AM
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Re: TAKE YOUR JAB! Modified RNA has a direct effect on DNA
2025
Anonymous Coward
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12/07/2020 07:40 AM
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Re: TAKE YOUR JAB! Modified RNA has a direct effect on DNA
Uncle Klaus says it's about transhumanism and thought reading and control. It's right out in the open... hiding in plain sight!!
Anonymous Coward
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12/07/2020 07:45 AM
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Re: TAKE YOUR JAB! Modified RNA has a direct effect on DNA
the mrna vaccines ia for the nano bots they already have us filled with.

essentially to bind those nanobots to our Dna so to the mainframe the machine can trace us no matter where we are.

also the purpose is to prepare our dna to passivly or agressivly integrate mecha organelles which are like biologic organelles but instead of being connected to God..it is connected to lucifer matrix.

the wheat and the chaff is to clean our temples of the false mecha organelles.

without mrna vaccines and rfid chip..those mecha organelles are useless.
Anonymous Coward
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12/07/2020 07:48 AM
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Re: TAKE YOUR JAB! Modified RNA has a direct effect on DNA
good to know, in case you wonder if the RNA released by the vaccine could possibly modify or regulate your DNA.

New field of research

Normally, epigenetic gene regulation is studied by examining dynamic modifications of DNA and proteins—so-called epigenetic modifications. The modifications can turn genes on or off without changing the underlying genetic code.

Less than 10 years ago, it was discovered that dynamic modifications also exist in RNA and that these have an important role to play in gene regulation


10 years ago scientist already knew that RNA plays a role in gene regulation

[link to phys.org (secure)]
 Quoting: Nagabonar666


and......that is the point in fact..all RNA does that... in fact... even the RNA made IN YOUR BODY.... I would study up a bit more. You would never have built a body inside your Mother if it was otherwise...
ICF

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12/07/2020 07:56 AM
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Re: TAKE YOUR JAB! Modified RNA has a direct effect on DNA
I do not consent

My body, my choice
Anonymous Coward
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12/07/2020 08:25 AM
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Re: TAKE YOUR JAB! Modified RNA has a direct effect on DNA
DNA

Long-term storage of genetic information; transmission of genetic information to make other cells and new organisms.

RNA

Used to transfer the genetic code from the nucleus to the ribosomes to make proteins. RNA is used to transmit genetic information in some organisms and may have been the molecule used to store genetic blueprints in primitive organisms.


so they'll make whatever proteins they want and ultimately change your DNA material, you cancerogenous fools
Anonymous Coward
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12/07/2020 08:26 AM
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Re: TAKE YOUR JAB! Modified RNA has a direct effect on DNA
Too many technicalities.

You do realize that every machine is made out of parts, even not machines, a table is made out of part, if you disassemble those parts, it won't function, nor as a table or a machine.

What they do now with all the information that they put out, is exactly for targeting the function. Cause if you disassemble the force, then it will be parts, as parts they are of no threat to anyone as they are easily handled and taken to recycle or put together as they please.

Ok, not technical is it.
Anonymous Coward
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12/07/2020 08:26 AM
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Re: TAKE YOUR JAB! Modified RNA has a direct effect on DNA
From the article:

“ In areas of DNA where RNA binds to one of the DNA threads in such a way that the complementary DNA thread becomes the sole thread (R-loop structures), the DNA stability will change if RNA is chemically modified by m6A.”

The mRNA in the vaccine has no human sequence such that it will ever bind with human DNA, and in fact does not even enter the nucleus.
 Quoting: Lover_Girl


DNA

Long-term storage of genetic information; transmission of genetic information to make other cells and new organisms.

RNA

Used to transfer the genetic code from the nucleus to the ribosomes to make proteins. RNA is used to transmit genetic information in some organisms and may have been the molecule used to store genetic blueprints in primitive organisms.

so they'll make whatever proteins they want and ultimately change your DNA material, you cancerogenous fools
marooned

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12/07/2020 08:27 AM

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Re: TAKE YOUR JAB! Modified RNA has a direct effect on DNA
Who else here expects this to be the BORG shot? With nanotek + dna edit = überslave versus tall regenerated "real" us'es. Nibiru returns for battle in "heaven" autobot vs decepticon.
 Quoting: Anonymous Coward 69845650


pcornsoda
emerald eye
Keeping an "eye out" for the truth.

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Re: TAKE YOUR JAB! Modified RNA has a direct effect on DNA
The following PDF paper was published in Jan, 2019 and deals with the Polyadenylation and nuclear export of mRNAs.

[link to www.jbc.org (secure)]

One of the things this paper states is the following (from the abstract-empahsis mine),

Although the components of this machinery have been identified and considerable functional insight has been achieved, a number of questions remain outstanding about mRNA nuclear export and how it is integrated into the nuclear phase of the gene expression pathway. Nuclear export factors mediate mRNA transit through nuclear pores to the cytoplasm, after which these factors are removed from the mRNA, preventing transcripts returning to the nucleus. However, as outlined in this review, several aspects of the mechanism by which transport factor binding and release is mediated remain unclear, as are the roles of accessory nuclear components in these processes. Moreover, the mechanisms by which completion of mRNA splicing and polyadenylation are recognized, together with how they are coordinated with nuclear export, also remain only partially characterized.”

"Also, “The transport of macromolecules, such as proteins and RNAs, between the cytoplasmic and nuclear compartments is mediated by nuclear pores that are huge macromolecular assemblies that span the nuclear envelope. Nuclear transport is an active, energy-requiring process and is highly selective. Because the pores function as a barrier to the passive diffusion of molecules larger than ~40kDa, only macromolecules that are bound to specific carrier molecules (“transport factors”) are able to move through them.

My questions are as follows:

1.If in Jan of 2019, “a number of questions remain outstanding about mRNA nuclear export and how it is integrated into the nuclear phase of the gene expression pathway” then how is it now so perfectly worked out and so absolutely certain in 2020?

2.What assurance do we have that the mRNA in the vaccine isn’t also coding for the production of transport factor proteins or other proteins that would allow it to move back into the nucleus? We are told it's only coding for the “spike protein” but have independent scientists been allowed to determine this, or is this information “proprietary”?

3.How do we know that the mRNA molecule contained in the vaccine is not smaller that 40kDa and therefore able to enter the nuclear pores thought the mechanism of passive diffusion, as passive diffusion can be an open door going both directions?

4. How do we know that the lipid encapsulation that apparently protects the vaccine mRNA and allows the vaccine mRNA to pass into the cell membrane does not also allow it to pass through the nuclear membrane or the nuclear pores ?

The above mentioned paper also makes the following statement, which causes me some concern as along with immune dysregulation comes the possible propensity for auto-immune disease(s)

“Errors or defects in the nuclear transcript modification steps or in mRNA nuclear export frequently result in impaired growth or death of cells and are associated with a broad range of different disease conditions. Consequently, these processes are closely coordinated and are coupled to the nuclear export of mRNA to ensure that only mature and completely processed transcripts reach cytoplasmic ribosomes for translation into proteins.”

5. Therefore, how do we know that the mRNA in the vaccine will ONLY function as a “mature and completely processed” product when it reaches the cytoplasmic ribosomes and begins to translate its protein(s)?

6. If the vaccine mRNA can get into the nucleus, and I personally think there may be an engineered "back-door" mechanism to do so, as mentioned in question #2 or is small enough to get through the nuclear pores by passive diffusion, then I think it is likely to have epigenetic effects on the nuclear DNA as covered in this thread.
All of the arguments starting with, "It can't get into the nucleus" then fly out the window.

I have many questions about this, these are just a few. My undergraduate background was weighted towards chemistry, so I would appreciate any input. Also, I haven’t had much sleep this weekend, so maybe my brain is fuzzy.

hfhfhf

Last Edited by emerald eye on 12/07/2020 08:53 AM
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while fear is the obstruction of all dreams.


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Hoseman

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12/07/2020 08:27 AM
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Re: TAKE YOUR JAB! Modified RNA has a direct effect on DNA
The vaccines contain RNA altering mind control technology which allows them to partly control your thoughts remotely by turning a part of your brain's RNA into a radio receiver and 'memory implanter.'

This is why Bill Gates and others are involved. Not because they care about the people. It's all about totalitarian global control ie. the Great Reset and this mind control technology is a planned part of it that they've been working on for decades.

They will be able to subconsciously implant short thoughts and beliefs via over the air radio frequency waves. You will not consciously know it and only think they are your original thoughts.

'trust the government'

'giving total control to government will make us all happy'

'people who resist the government are dangerous terrorists'

'our personal freedoms and rights are too dangerous to the whole of the people'

'do whatever police or military tell you do, without question'

'I do not need or want personal belongings'

'It's best if only the government owns and controls everything'


Do not take the vaccine even if you have to lose your job over it. Once you take the vaccine there is no reversing it.
 Quoting: Anonymous Coward 77996433



Yep. What is Bill Gates? He's a computer programmer - one of the world's if not the world's most innovative and influential computer programmers. Why is a computer programmer now so much a key part of this vaccine? Answer: because there's a part of this which is about 'computer programming' your brain.


[link to www.nbcnews.com (secure)]

[link to www.forbes.com (secure)]

[link to www.independent.co.uk (secure)]



They may also be able to read your thoughts with this and that's even scarier.
 Quoting: Anonymous Coward 79567835


Not even close. He was a pretty good programmer at first. He is basically a businessman whose tactics Michael Corleone would admire.
Anonymous Coward
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12/07/2020 08:27 AM
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Re: TAKE YOUR JAB! Modified RNA has a direct effect on DNA
I do not consent

My body, my choice
 Quoting: ICF


True, but you are just a part, not a whole. As a part you will be face by no other choice other than to comply, want it or not.
Anonymous Coward
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12/07/2020 08:28 AM
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Re: TAKE YOUR JAB! Modified RNA has a direct effect on DNA
this is the Neo-Holocaust 2.0, just that instead of the yellow start around your arm, you'll have nanoparticle starts running through your bloodstream
Anonymous Coward
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12/07/2020 08:29 AM
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Re: TAKE YOUR JAB! Modified RNA has a direct effect on DNA
this is the Neo-Holocaust 2.0, just that instead of the yellow star around your arm, you'll have nanoparticle stars running through your bloodstream
 Quoting: Anonymous Coward 79356258


The poster child for the talk was the mRNA vaccine that had just been reported on in the New England Journal of Medicine; the Moderna candidate, whose promising early results were described, relies on nanoparticle delivery.

“One of the heroes of this story is the nanoparticle,” said Anderson, professor of chemical engineering and of health sciences and technology at the MIT Koch Institute for Integrative Cancer Research.

“Encapsulating RNA in a package that can travel through the bloodstream and reach target cells is quite a challenge,” he explained. “Endocytosis is how it gets into the cell. Then it has to escape the endosome and release its payload. Decades of work have gone into this. It isn’t easy.”

Years of experiments on animal models have shown that injected nanoparticles usually end up in the organs that filter blood—liver, spleen, bone marrow and kidney.

But, as Anderson pointed out, “RNA or DNA is simply not a great drug. It does not cross cellular membranes. We need expression of these constructs to get function.”

An important precursor to nanoparticle vaccinology is basic research on small interfering RNA (siRNA), a breakthrough that won the 2006 Nobel prize. siRNAs can seek and destroy complementary strands of RNA. “In essence, we can turn off any gene we want,” Anderson said.

He described three key steps to turn nucleic acids into drugs: sequence selection, chemical modification and encapsulation.

“The first question with nanoparticles is, what do you build it out of?” Early biomaterials, such as the artificial heart, were made of material found in ladies’ girdles—polyether urethane. The tubing used for dialysis originated in sausage casing (cellulose acetate). The first vascular grafts came from the world of clothing—the synthetic fabric Dacron.

[link to nihrecord.nih.gov (secure)]
Anonymous Coward
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12/07/2020 08:34 AM
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Re: TAKE YOUR JAB! Modified RNA has a direct effect on DNA
The following PDF paper was published in Jan, 2019 and deals with the Polyadenylation and nuclear export of mRNAs.

[link to www.jbc.org (secure)]

One of the things this paper states is the following (from the abstract-empahsis mine),

Although the components of this machinery have been identified and considerable functional insight has been achieved, a number of questions remain outstanding about mRNA nuclear export and how it is integrated into the nuclear phase of the gene expression pathway. Nuclear export factors mediate mRNA transit through nuclear pores to the cytoplasm, after which these factors are removed from the mRNA, preventing transcripts returning to the nucleus. However, as outlined in this review, several aspects of the mechanism by which transport factor binding and release is mediated remain unclear, as are the roles of accessory nuclear components in these processes. Moreover, the mechanisms by which completion of mRNA splicing and polyadenylation are recognized, together with how they are coordinated with nuclear export, also remain only partially characterized.”

"Also, “The transport of macromolecules, such as proteins and RNAs, between the cytoplasmic and nuclear compartments is mediated by nuclear pores that are huge macromolecular assemblies that span the nuclear envelope. Nuclear transport is an active, energy-requiring process and is highly selective. Because the pores function as a barrier to the passive diffusion of molecules larger than ~40kDa, only macromolecules that are bound to specific carrier molecules (“transport factors”) are able to move through them.

My questions are as follows:

1.If in Jan of 2019, “a number of questions remain outstanding about mRNA nuclear export and how it is integrated into the nuclear phase of the gene expression pathway” then how is it now so perfectly worked out and so absolutely certain in 2020?

2.What assurance do we have that the mRNA in the vaccine isn’t also coding for the production of transport factor proteins or other proteins that would allow it to move back into the nucleus? We are told it's only coding for the “spike protein” but have independent scientists been allowed to determine this, or is this information “proprietary”?

3.How do we know that the mRNA molecule contained in the vaccine is not smaller that 40kDa and therefore able to enter the nuclear pores thought the mechanism of passive diffusion, as passive diffusion can be an open door going both directions?

4. How do we know that the lipid encapsulation that apparently protects the vaccine mRNA and allows the vaccine mRNA to pass into the cell membrane does not also allow it to pass through the nuclear membrane or the nuclear pores ?

The above mentioned paper also makes the following statement, which causes me some concern as along with immune dysregulation comes the possible propensity for auto-immune disease(s)

“Errors or defects in the nuclear transcript modification steps or in mRNA nuclear export frequently result in impaired grow or death of cells and are associated with a broad range of different disease conditions. Consequently, these processes are closely coordinated and are coupled to the nuclear export of mRNA to ensure that only mature and completely processed transcripts reach cytoplasmic ribosomes for translation into proteins.”

5. Therefore, how do we know that the mRNA in the vaccine will ONLY function as a “mature and completely processed” product when it reaches the cytoplasmic ribosomes and begins to translate its protein(s)?


I have many questions about this, these are just a few. My undergraduate background was weighted towards chemistry, so I would appreciate any input. Also, I haven’t had much sleep this weekend, so maybe my brain is fuzzy.

hfhfhf
 Quoting: emerald eye


we don't care about what questions you might have. Trust the scientists and those that care for keeping you safe and for doing that you have to get vaccinated so to show how you care for the others and not only yourself, only together we can put away this deadly virus that has brought abnormality and return to normality again and enjoy our life without the urgent measures taken for our health safety as humans in whole, stay safe, and follow the guidelines given by your local health department and we all will watch this sad part of our life at the future with gratitude towards all those that did the best they could for taking us out of this and kept us safe and healthy. :)
Anonymous Coward (OP)
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12/07/2020 08:36 AM
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Re: TAKE YOUR JAB! Modified RNA has a direct effect on DNA
You do realize mRNA is not RNA?
 Quoting: Anonymous Coward 70883671


wrong. a messenger RNA (mRNA) is a type of RNA. It is a RNA molecule

[link to www.genome.gov (secure)]

If they can alter / modify RNA, who is to say they can not modify mRNA?
Anonymous Coward
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12/07/2020 08:37 AM
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Re: TAKE YOUR JAB! Modified RNA has a direct effect on DNA
They don't even have enough shots to give everyone their first shot.



HOW ARE THEY GOING TO HAVE ENOUGH SHOTS TO GIVE EVERYONE THEIR SECOND SHOT A WEEK LATER?
 Quoting: Anonymous Coward 79719774


Whoa





GLP