COVID19 HOLY SH&T A Research Thread

If it is true that one of the spreading versions of Coronavirus has the HIV envelope.

Nobody on earth will have heard immunity to that version of the virus.

Part 2

Herd Immunity

I’ll just quote this since it is a very touted way for populations to have immunity from various pathogens.

[link to en.m.wikipedia.org (secure)]

Herd immunity (also called herd effect, community immunity, population immunity, or social immunity) is a form of indirect protection from infectious disease that occurs when a large percentage of a population has become immune to an infection, whether through previous infections or vaccination, thereby providing a measure of protection for individuals who are not immune.[1][2] In a population in which a large proportion of individuals possess immunity, such people being unlikely to contribute to disease transmission, chains of infection are more likely to be disrupted, which either stops or slows the spread of disease.

Simply put, there is no evidence that people can develop herd immunity to COVID19.

There is no research published that shows this to be factual and there is only speculation amongst leaders and news papers touting this.

Think about this for a minute.

There are several Common Cold strains that are Corona Virus’s and that have been in circulation in populations for generations. These same strains reinfect populations every year around the globe.

One of which is known as OC43.

OC43 has been circulating in populations since around 1890 according to this paper.

[link to www.scielo.br]

Why no herd immunity? High mutation rates.

COVID19 has already demonstrated a high mutation rate.

So in short, I have very little belief that Herd Immunity to COVID19 will develop amongst a global population any time soon.

Part 3

ADE

This is the BIG one in my opinion.

-ADE could explain why there are much higher case fatality rates among older populations.

-ADE could also spell why COVID19 could wipeout everything. And I do mean everything.

-ADE could also mean that no vaccine could be developed for SARS-CoV-2 which is the virus that causes COVID19.

What is ADE?

Antibody Dependent Enhancement.

Antibody-dependent enhancement of virus infection and disease.

[link to www.ncbi.nlm.nih.gov (secure)]


“In general, virus-specific antibodies are considered antiviral and play an important role in the control of virus infections in a number of ways. However, in some instances, the presence of specific antibodies can be beneficial to the virus. This activity is known as antibody-dependent enhancement (ADE) of virus infection.”



Antibody-Dependent Enhancement (ADE) of infection and its possible role in the pathogenesis of influenza

[link to www.ncbi.nlm.nih.gov (secure)]

“Antibody-dependent enhancement (ADE) of viral replication has been documented for viruses, such as dengue virus, Ross river virus, other alpha and flaviviruses, HIV and also influenza virus. ADE occurs when non-neutralised virus-antibody complexes find alternative receptors and routes entry into the cell via the Fc-receptor pathway. ADE has been demonstrated predominantly in macrophages or Fc-receptor bearing cells although other types of cells have also been occasionally implicated (1,2). Thus, viruses may find routes of entry to cells lacking the usual virus receptor.”




And here we have a major issue.

Molecular Mechanism for Antibody-Dependent Enhancement of Coronavirus Entry.

[link to www.ncbi.nlm.nih.gov (secure)]

“Antibody-dependent enhancement (ADE) of viral entry has been a major concern for epidemiology, vaccine development, and antibody-based drug therapy. However, the molecular mechanism behind ADE is still elusive. Coronavirus spike protein mediates viral entry into cells by first binding to a receptor on the host cell surface and then fusing viral and host membranes....”

Specifically

Is COVID-19 receiving ADE from other coronaviruses?

[link to www.sciencedirect.com (secure)]

“One possible answer is antibody dependent enhancement (ADE) of SARS-CoV-2 due to prior exposure to other coronaviruses. ADE modulates the immune response and can elicit sustained inflammation, lymphopenia, and/or cytokine storm, one or all of which have been documented in severe cases and deaths. ADE also requires prior exposure to similar antigenic epitopes, presumably circulating in local viruses”

And, they know this!

Fauci warned that a vaccine could make the disease worse.
I can’t quote the article that contains this quote as it is banned here but it is from a MSM source. You can look it up.
More later.

REAL DATA IS STARTING TO LEAK OUT - NYC

[link to ibb.co (secure)]

Another Source for Fauci statement.

[link to www.technologyreview.com (secure)]

That’s in part because vaccines can sometime make diseases worse, not better. Hotez says the effect is called “immune enhancement,” and that he saw it with one version of his SARS vaccine, which sickened mice.

In his podcast with JAMA, Fauci cautioned about what could occur if you “get what you think is a vaccine, and just give it to people.” Because vaccine recipients are healthy, there’s not much margin for error: “So we are not going to have a vaccine in the immediate future, which tells us we have to reply on the public measures.”

And this is exactly what you see in past development efforts for other Corona Virus vaccines.

Part 4

So, what does ADE mean for vaccine development.

If you read in detail what I’ve posted above, you will understand that vaccine development for SARS-CoV-2 is a perilous endeavor at best and an unattainable goal with our current technology at worst.

This paper highlights just this fact when undertaking the development of SARS-CoV-2 close relative SAR-CoV.
To date, there is no vaccine against SARS and this paper demonstrates different avenues that were investigated to develop a vaccine.

I’m quoting one of several statements in this paper about ADE, SARS, and vaccine safety.

[link to www.ncbi.nlm.nih.gov (secure)]

SARS Vaccine Development


“The S protein of FIPV expressed by recombinant vaccinia can cause antibody-dependent enhancement of disease if vaccinated animals are subsequently infected with wild-type virus (32). Our previous studies on HIV-1 showed that antibodies against some immunodominant epitopes in the HIV-1 envelope glycoprotein could enhance infection by heterologous HIV-1 strains (33). Most recently, Yang et al. (6) demonstrated that the polyclonal and monoclonal antibodies against S protein of the late SARS-CoV (Urbani strain) could neutralize infection by the relevant late SARS-CoV strains. However, these antibodies enhanced infection by an early human SARS-CoV isolate (GD03T0013) and the civet SARS-CoV–like viruses. “


———

The old 1 star retards strike.

This is all based on research data. Guess some illiterate low IQ types can’t process.

I agree. Keep reading, more to come.

The disease is sevrvs created using sendai virus and vaccine for 3 other virus. Look it up

BUMP

Part 5

What does ADE have to do with increased CFR among older populations?

We will go back to this paper.

Is COVID-19 receiving ADE from other coronaviruses?

[link to www.sciencedirect.com (secure)]

“ADE modulates the immune response and can elicit sustained inflammation, lymphopenia, and/or cytokine storm, one or all of which have been documented in severe cases and deaths. ADE also requires prior exposure to similar antigenic epitopes, presumably circulating in local viruses, making it a possible explanation for the observed geographic limitation of severe cases and deaths.”

And, here is where it gets interesting.

Everything I’ve posted up to this point has been backed by research and this is where I diverge into the theoretical, although there has been some solid evidence this could be true posted prior to this assertion.


The Common Cold

Repeated prior exposure to other Corona Virus types and the antibodies the immune system has produced over the course of one’s lifetime could be driving these higher death rates.

As mentioned earlier, there are several common colds that are corona viruses.

Older populations have much higher exposure rates and in turn more antibodies to these common cold viruses.

I believe COVID-19 exploits these antibodies through ADE to gain entry at a much higher rate, is more infective, and more lethal due to this mechanism in these older populations.

———

What does all of this mean for our future?

5 stars for thought provoking discussion.... I've been asking myself for a couple days if this virus is a slow ELE..I'm not sure I want to think about it.

Thank you! Appreciate it.

This thread is for thinkers and you are obviously giving this enough thought to understand the implications of all of the above.

How do you feel about immunity OP? It seems there is a good deal of the population that holds up pretty well against this virus ... It seems you may be heading down the ELE path but that doesn't seem to be the case.

Fascinating thread OP, I definitely need to come back to read more in depth. I am particularly interested in this bit:

What if I told you that there is a mechanism by which SAR-CoV-2 could reinfect and be even more lethal amongst those reinfected than the first infection?


I believe that to be true myself - curious to know what your thoughts on that are, what research you have seen that leads to that hypothesis.

5 stars.

where is the documented proof that a healthy person with no symptoms who hasn't been sick in years and spread corona virus and kill someone else?

also where is the proof it has a 14-28 day incubation period.

these are the 2 lies they used to close the globe some I'm looking for factual information. because it seems like a lie

Keep giving us this thought provoking info! You’re appreciated, thank you!
I’m older so this is important to me! 5*!

Are you the dude from Zerosense that posted some amazing stuff. Actually, best stuff I've read on the topic...and most disturbing.

[link to barbarous-reliquary.36082.n8.nabble.com]

I'm still processing this one

GLP has been open to hundreds of operatives recently. No thread untouched. If the goal was to discredit the site, it's working on me. So many tiresome comments and ratings.

Great stuff.




Just watched this talks about the hiv components.

14-28 day avg. time for reinfection.

so abbreviation of your analysis is....
There is no cure.

It attacks the body much like aids and uses our immune system against us.

It is highly contagious which means there is no way to stop it ever in a world of millions infected.

It's mutation process is so quick that no one will become immune, and it will reinfect those who have antibioties and it will be worse the next time they get the upgraded version.

The healthcare workers will surely all be wiped out first, because they all have it if they've treated it.

And the only people in the world who will survive will be

1. those who avoid humanity as a whole, survivors and preppers who may last the 10 years it takes to cycle enough times to kill everyone.

2. those living in such remote areas that they never come in contact with the outside world.


Great, so we should kinda do what Prince says huh?
Party like it's 1999? I mean why not? If the doom u post is true, it's kinda like saying ur going to get nuked and die. Do you want to b at ground zero where the nuke hits, or do u want to suffer and die a slow death from radioactive fallout one or two years later after society collapses anyway and the quality of life is destroyed and gone.

I understand most on glp have dreamed of this day. But honestly. Is it a reality u truly want to live in? What is the quality of everyones lives going to b now?

1/2 of Americans have a pre-existing condition regardless of age. You're willing to throw them all under the bus? It's fine if the answer is yes, I just want the number of truly susceptible individuals acknowledged by someone that clearly wants to take this path.

"What if I told you that there is a mechanism by which SAR-CoV-2 could reinfect and be even more lethal amongst those reinfected than the first infection?"

One of my closest friends fell ill with flu like symptoms in early Feb, said he felt terrible for about a week, but then recovered fully. Two weeks later he woke feeling bad again, a few hours later he called his GF complaining of serious trouble breathing, she called EMS and headed to his house. Within 18 minutes of that call he was dead. He was revived at the scene, but pronounced brain dead an hour later at the hospital. Cause of death was called "unknown", doctors stated his lungs had filled with fluid very quickly and he had drowned.


Sound familiar?

Bump to keep in my active threads.

Sounds like doom on.

Today has been rough, the underlying 24/7 state of tension is getting to me.

Yes, it is likely that herd immunity is not possible and they won't be able to find a vaccine for this either. Perhaps we can work on more effective treatments.

Great thread OP, this is a real worry and is hopefully not the case but is highly possible.

You mentioned dengue fever doing the same and yes dengue fever can be very nasty if reinfection with another strain occurs, resulting in dengue haemorragic fever.

Scary stuff.

The basis of good health is known. In spite of this, many people are in poor health. Those with poor health age faster and die younger. However, we all die.

Should it be otherwise?