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Metabolic switch may bring on chronic fatigue syndrome

 
cerebrose
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02/14/2017 02:09 PM
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Metabolic switch may bring on chronic fatigue syndrome
[...]the cells of people with CFS stop making as much energy from sugar as usual, and start relying more on lower-yielding fuels, such as amino acids and fats. This kind of metabolic switch produces lactate, which can cause pain when it accumulates in muscles.

Together, this would explain both the shortness of energy, and why even mild exercise can be exhausting and painful.

Øystein Fluge of Haukeland University Hospital in Bergen, Norway, and his colleagues studied amino acids in 200 people with CFS, and 102 people without it. The levels of some amino acids in the blood of women with CFS was abnormally low – specifically for the types of amino acid that can be used by the body as an alternative fuel source.

[...]

Both sexes had high levels of several enzymes known to suppress pyruvate dehydrogenase (PDH), an enzyme vital for moving carbohydrates and sugars into a cell’s mitochondria – a key step for fully exploiting sugar for energy.

[...]

The result is not unlike starvation, says Armstrong. “When people are facing starvation, the body uses amino acids and fatty acids to fuel energy for most cells in the body, to keep glucose levels vital for the brain and muscles as high as possible.”

“We think that no single enzyme in metabolism will be the answer to CFS, just as no single enzyme is the ‘cause’ of something like hibernation,” says Robert Naviaux of the University of California at San Diego, who has found depletion of fatty acids in patients suggesting they were diverted as fuel.

So what could flick the switch to a different method of metabolism? Fluge’s team thinks that a person’s own immune system may stop PDH from working, possibly triggered by a mild infection.
 Quoting: [link to www.newscientist.com (secure)]

Without energy life would be extinguished instantaneously, and the cellular fabric would collapse. - Albert Szent-Györgyi

What the midnight creep said to the fine black sheep: Help me stir her stolen blood with the jealousy of death above... [link to musescore.com (secure)]
Anonymous Coward
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02/14/2017 02:17 PM
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Re: Metabolic switch may bring on chronic fatigue syndrome
[...]the cells of people with CFS stop making as much energy from sugar as usual, and start relying more on lower-yielding fuels, such as amino acids and fats. This kind of metabolic switch produces lactate, which can cause pain when it accumulates in muscles.

Together, this would explain both the shortness of energy, and why even mild exercise can be exhausting and painful.

Øystein Fluge of Haukeland University Hospital in Bergen, Norway, and his colleagues studied amino acids in 200 people with CFS, and 102 people without it. The levels of some amino acids in the blood of women with CFS was abnormally low – specifically for the types of amino acid that can be used by the body as an alternative fuel source.

[...]

Both sexes had high levels of several enzymes known to suppress pyruvate dehydrogenase (PDH), an enzyme vital for moving carbohydrates and sugars into a cell’s mitochondria – a key step for fully exploiting sugar for energy.

[...]

The result is not unlike starvation, says Armstrong. “When people are facing starvation, the body uses amino acids and fatty acids to fuel energy for most cells in the body, to keep glucose levels vital for the brain and muscles as high as possible.”

“We think that no single enzyme in metabolism will be the answer to CFS, just as no single enzyme is the ‘cause’ of something like hibernation,” says Robert Naviaux of the University of California at San Diego, who has found depletion of fatty acids in patients suggesting they were diverted as fuel.

So what could flick the switch to a different method of metabolism? Fluge’s team thinks that a person’s own immune system may stop PDH from working, possibly triggered by a mild infection.
 Quoting: [link to www.newscientist.com (secure)]

 Quoting: cerebrose


interesting. i wonder what could kick the switch back to the default setting?
Anonymous Coward
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02/14/2017 02:23 PM
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Re: Metabolic switch may bring on chronic fatigue syndrome
Switch to a whole-foods, plant based diet.

[link to nutritionfacts.org]
cerebrose  (OP)

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02/14/2017 03:27 PM
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Re: Metabolic switch may bring on chronic fatigue syndrome
interesting. i wonder what could kick the switch back to the default setting?
 Quoting: Anonymous Coward 45320898


Some obstacles that come to mind: in general, inflammatory, excitatory irritants which waste energy - promoters of estrogen, serotonin, glutamate, cortisol, adrenaline and other agents of lipolysis (fat liberation) & sources/promoters of lipid peroxidation (LP).

Some aids: The quinones are a promising lot (think coQ10 and, interestingly, vitamin K), other fat-solubles (vitamin E protects against LP), suppressors of parathyroid hormone (PTH) (D, calcium), which disrupts glucose metabolism, & enhancers of proper calcium distribution (E/K). Dopamine support to combat prolactin & serotonin, which counters insulin function. GABAergic things to shield from excitotoxicity which hinders proper cellular functionality; stifling inflammation will also have this effect. B vitamins of course, particularly B1, B3 & biotin. Dietary liver seems to house an exceptional abundance of helpful, anti-stress nutrients. Cox-2 inhibitors (like E & aspirin) will counter the excitatory effect of the glycine antagonistic prostaglandins derived from LP.
Anything that promotes thyroid function & veritably reduces stress, without compromising immune function.
Without energy life would be extinguished instantaneously, and the cellular fabric would collapse. - Albert Szent-Györgyi

What the midnight creep said to the fine black sheep: Help me stir her stolen blood with the jealousy of death above... [link to musescore.com (secure)]





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