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Message Subject Two kids with a mutation in the gene encoding MOGS immune to many viruses including influenza, herpes, dengue fever, hepatitis C, and HIV.
Poster Handle Kirk
Post Content
Sounds like a mutation you can keep

Early in life, they each had a complex disorder characterized by dysmorphic facial features, generalized hypotonia, seizures, global developmental delay, cerebral atrophy, a small corpus callosum, optic-nerve atrophy, sensorineural hearing loss, hypoplastic genitalia, chronic constipation, and recurrent bone fractures; severe hypogammaglobulinemia was also diagnosed. The patients were evaluated for the frequency of febrile episodes, confirmed or suspected infections, receipt of antibiotics or intravenous immune globulin, and complications associated with infectious diseases and live viral vaccines. Patient 1 had had two invasive infections: a pneumococcal pneumonia with empyema (no previous pneumococcal vaccination) at the age of 9 years and a nosocomial Staphylococcus aureus osteomyelitis after surgical osteosynthesis at the age of 10 years; Patient 2 had had two episodes of otitis media (at 4 and 5 years of age), the first one with effusion, and had had one urinary tract infection (>105 colony-forming units of Escherichia coli per milliliter) at the age of 6 years. No other severe or recurrent infections were reported, and no long-term anti-infectious therapies were reported. The patients had no complications after routine vaccinations, including live viral vaccines. Patient 1 has attended a special education program since kindergarten and has therefore presumably been exposed to infectious diseases; Patient 2 is homeschooled owing to a more severe neurologic phenotype.
 
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