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Subject The Superbug debugged , reason for bacterial resistance to antibiotics found !
Poster Handle Urod
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Ya , take a sight of relieve , no need to worry about the Suberbugs .

[link to english.farsnews.com]

How Bacteria Become Resistant to Antibiotics

TEHRAN (FNA)- For the first time, scientists have been able to paint a detailed chemical picture of how a particular strain of bacteria has evolved to become resistant to antibiotics.

The research is a key step toward designing compounds to prevent infections by recently evolved, drug-resistant "superbugs" that often are found in hospitals, as well as in the general population.

A paper describing the research, by a team led by Squire Booker, an associate professor in the department of chemistry and the department of biochemistry and molecular biology at Penn State University, will be posted by the journal Science on its early-online Science Express site on 28 April. This paper is a continuation of research led by Booker published in another paper in Science earlier this month....

... "What had perplexed scientists is that the locations to which RlmN and Cfr add molecular tags are chemically different from all others to which tags routinely are appended, and should be resistant to modification by standard chemical methods," Booker said. "What we've discovered here is so exciting because it represents a truly new chemical mechanism for methylation. We now have a very clear chemical picture of a very clever mechanism for antibiotic resistance that some bacteria have evolved."

Booker also said he believes the next step will be to use this new information to design compounds that could work in conjunction with typical antibiotics. "Because we know the specific mechanism by which bacterial cells evade several classes of antibiotics, we can begin to think about how to disrupt the process so that standard antibiotics can do their jobs," he said.
 
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